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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Clinical significance of unexplained elevated maternal serum alpha feto-protein in second trimester of pregnancy
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Clinical significance of unexplained elevated maternal serum alpha feto-protein in second trimester of pregnancy

机译：妊娠中期孕妇无法解释的血清血清甲胎蛋白升高的临床意义

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Background: Alpha-fetoprotein (AFP) is the major serum protein in the embryonic stage and in the early fetal stage. The aim of this study was to measure maternal serum AFP levels in second trimester between 15-20 weeks of gestation and to determine whether unexplained elevated MSAFP levels is an effective predictor of adverse pregnancy outcome among Indian population. Methods: This study was a prospective observational study, carried out on 400 pregnant women. Maternal serum alpha-fetoprotein (MSAFP) was measured between 15 and 20 weeks of gestation after excluding congenital malformation or birth defects. MSAFP level was determined by using a radio-immunoassay technique. Women with MSAFP level 2.0 MoM was considered as abnormal while MSAFP level≤ 2.0 MoM was considered as normal. All women were followed up till delivery and pregnancy outcomes were noted and compared between two groups. Results: Women with elevated MSAFP had significantly higher adverse pregnancy outcomes (75.4%) compared to women with MSAFP ≤2.0 MoM (26.1%) (p0.0001 with relative risk of 2.89, 95% confidence interval 2.276 -3.667). Conclusions: Unexplained elevated MSAFP has high sensitivity, specificity, positive predictive value and negative predictive value in predicting adverse pregnancy outcomes. It would, therefore be worthwhile screening pregnant women in second trimester for maternal serum alpha-fetoprotein levels as it would help to identify high risk pregnancies and allow close antenatal survillence for better pregnancy outcome.
机译：背景：甲胎蛋白（AFP）是胚胎期和胎儿早期的主要血清蛋白。这项研究的目的是在妊娠15-20周之间测量孕中期孕妇的血清AFP水平，并确定无法解释的MSAFP水平升高是否是印度人群不良妊娠结局的有效预测指标。方法：本研究是对400名孕妇进行的一项前瞻性观察性研究。在排除先天性畸形或出生缺陷后，在妊娠15至20周之间测量了孕妇血清甲胎蛋白（MSAFP）。 MSAFP水平是通过放射免疫分析技术确定的。 MSAFP水平> 2.0 MoM的妇女被认为是异常的，而MSAFP水平≤2.0MoM的妇女被认为是正常的。对所有妇女进行随访，直到分娩和妊娠结局得到记录并在两组之间进行比较。结果：与MSAFP≤2.0MoM的女性（26.1％）相比，MSAFP升高的女性的不良妊娠结局明显更高（75.4％）（p <0.0001，相对风险为2.89，95％置信区间2.276 -3.667）。结论：无法解释的MSAFP升高在预测不良妊娠结局方面具有很高的敏感性，特异性，阳性预测值和阴性预测值。因此，值得在孕中期筛查孕妇血清中的甲胎蛋白水平，因为这将有助于识别高危妊娠并允许密切的产前围产期以提高妊娠结局。

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