...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Therapeutic efficacy of low dose (Dhaka regimen) versus high dose (Pritchard regimen) magnesium sulphate for management of eclampsia and impending eclampsia
【24h】

Therapeutic efficacy of low dose (Dhaka regimen) versus high dose (Pritchard regimen) magnesium sulphate for management of eclampsia and impending eclampsia

机译：低剂量（达卡方案）与高剂量（Pritchard方案）硫酸镁治疗子痫和即将来子痫的疗效

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: To compare the efficacy of low dose (Dhaka regimen) vis-a vis high dose (Pritchard regimen) magnesium sulphate in management of eclampsia and impending eclampsia. Methods: The open-label, comparative study was conducted on 90 pregnant patients. They were admitted to emergency Department of Obstetrics and Gynaecology, Government Medical College, Amritsar with eclampsia or impending eclampsia. 10 patients dropped out at various stages of study and finally, 80 were enrolled and randomized (1:1 ratio) into two groups. Group-1, N=40 were given low dose MgSOsub4/sub?(Dhaka regime) and Group-2, N=40 were given high dose MgSOsub4/sub?(Pritchard). Termination of pregnancy was done as per Bishop’s score, gestation age, maternal and fetal status. Primary outcome measure was therapeutic efficacy of equivalence for control of seizures whereas secondary outcome was adverse side-effects of both the regimens. Results: Mean age in Group-1 was 24.90±4.02 years and that of Group-2 was 25.67±3.79 years. Antepartum eclampsia was the most common diagnosis among groups i.e., 47.5% and 55% respectively. After treatment, the seizure control was 97.5% in Group-1 and 100% in Group-2 with comparable results (??sup2/sup=1.013; p=0.314). However, highly significant difference was observed among dosage of MgSOsub4?/subthat was required for control of seizure (23.75±2.71 gm versus 41.35±4.76 gm; p0.001). Group-1 showed lower incidence of side-effects that is, loss of deep tendon reflex as compared to Group-2, but neonatal outcomes were comparable in both groups. Conclusions: Low dose (Dhaka regimen) was equally effective in control of seizures as compared to high dose (Pritchard regimen) with lower incidence of side-effects.
机译：背景：比较低剂量（达卡方案）与高剂量（Pritchard方案）硫酸镁在治疗子痫和即将发生的子痫中的疗效。方法：对90名孕妇进行了开放标签的比较研究。他们因子痫或即将发生子痫而入院阿姆利则政府医学院急诊科。 10名患者在研究的各个阶段退出，最后有80名患者入组并按1：1比例随机分为两组。第1组，N = 40给予低剂量MgSO 4 ？（达卡方案），第2组，N = 40给予高剂量MgSO 4 ？（Pritchard） 。根据Bishop的评分，胎龄，孕产妇和胎儿状况终止妊娠。主要结局指标是等效控制癫痫发作的疗效，而次要结局则是两种方案的不良副作用。结果：第一组的平均年龄为24.90±4.02岁，第二组的平均年龄为25.67±3.79岁。产前子痫是各组中最常见的诊断，分别为47.5％和55％。治疗后，第1组的癫痫发作控制率为97.5％，第2组的癫痫发作控制率为100％，结果相当（Δε 2 = 1.013; p = 0.314）。但是，在控制癫痫发作所需的MgSO 4 剂量之间观察到高度显着差异（23.75±2.71 gm对41.35±4.76 gm; p <0.001）。与第2组相比，第1组的副作用发生率较低，即深腱反射消失，但两组的新生儿结局相当。结论：与高剂量（Pritchard方案）相比，低剂量（达卡方案）在控制癫痫发作方面同样有效，且副作用发生率较低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号