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首页> 外文期刊>International journal of rheumatology >Vascular Changes in Bleomycin-Induced Scleroderma
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Vascular Changes in Bleomycin-Induced Scleroderma

机译：博来霉素诱导的硬皮病中的血管变化

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Systemic sclerosis (SSc) is characterized by vascular injury, immunological abnormalities, and fibrosis of the skin as well as various internal organs. Vascular impairment is the early manifestation and plays a fundamental role in the pathogenesis of SSc. Recent studies suggest that complex interactions among the endothelial cells, pericytes, smooth muscle cells, and fibroblasts are involved in the systemic vasculopathy in SSc, and histological feature of proliferation of vascular wall is seen in the lesional scleroderma skin at the late stage of disease. One of the most representative mouse models for scleroderma is the bleomycin-induced scleroderma; however, aspects of vascular alteration have not been described in detail so far. A number of studies have shown that bleomycin stimulates endothelial cells and fibroblasts to induce proinflammatory and fibrogenic cytokines, apoptosis, reactive oxygen species, and so on. This paper makes a focus on the vascular involvement in the bleomycin-induced murine scleroderma.
机译：系统性硬化症（SSc）的特征是血管损伤，免疫异常，皮肤以及各种内部器官的纤维化。血管损伤是SSc的早期表现，在SSc的发病机理中起着重要作用。最近的研究表明，SSc的系统性血管病涉及内皮细胞，周细胞，平滑肌细胞和成纤维细胞之间的复杂相互作用，并且在疾病晚期的病变硬皮病皮肤中可见血管壁增殖的组织学特征。博莱霉素诱导的硬皮病是最具代表性的硬皮病小鼠模型之一。然而，到目前为止，尚未详细描述血管改变的各个方面。大量研究表明，博来霉素刺激内皮细胞和成纤维细胞诱导促炎性和纤维化细胞因子，细胞凋亡，活性氧等。本文着重于博来霉素诱导的鼠硬皮病中的血管受累。

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