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首页> 外文期刊>American Journal of Medicine Studies >Multidrug Resistance-1 Gene Polymorphisms in Steroid Resistance Nephrotic Syndrome with Different Pathology
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Multidrug Resistance-1 Gene Polymorphisms in Steroid Resistance Nephrotic Syndrome with Different Pathology

机译：类固醇耐药性肾病综合征的多药耐药性-1基因多态性

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MDR-1 expression in lymphocytes has been reported to be negatively correlated with the response to prednisone in children with nephrotic syndrome (NS). The aim of this study was to evaluate if MDR-1 gene polymorphisms are different according to pathological type of steroid resistant NS or not. We studied 15 cases with SRNS; 11 cases with focal segmental glomerulosclerosis (FSGS) and 4 cases with mesangioproliferative glomerulonepheritis. All cases were tested for 1 (MDR-1) genetic polymorphisms [C1236T, G2677T (A) and C3435T] polymorphisms; this was done by PCR-based restriction fragment length polymorphism (RFLP). By comparing these polymorphisms between FSGS cases versus mesangioproliferative glomerulonepheritis cases we didn’t find any significant difference in either genotypes or alleles. Thus we concluded that there is no relation between pathological type of SRNS and MDR-1 gene polymorphism in the three tested sites [C1236T, G2677T/A, C3435T].
机译：据报道，患有肾病综合征（NS）的儿童中淋巴细胞中的MDR-1表达与对泼尼松的反应呈负相关。这项研究的目的是评估是否MDR-1基因多态性根据类固醇抗性NS的病理类型而不同。我们研究了15例SRNS;局灶性节段性肾小球硬化症（FSGS）11例，中血管增生性肾小球肾炎4例。测试所有病例的1（MDR-1）基因多态性[C1236T，G2677T（A）和C3435T]多态性;这是通过基于PCR的限制性片段长度多态性（RFLP）完成的。通过比较FSGS病例和血管增生性肾小球肾炎病例之间的这些多态性，我们在基因型或等位基因上均未发现任何显着差异。因此，我们得出结论，在三个测试位点[C1236T，G2677T / A，C3435T]中，SRNS的病理类型与MDR-1基因多态性之间没有关系。

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