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首页> 外文期刊>International Journal of Reproductive Medicine >Comparative Evaluation of the Impact of Subacute Exposure of Smokeless Tobacco and Tobacco Smoke on Rat Testis
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Comparative Evaluation of the Impact of Subacute Exposure of Smokeless Tobacco and Tobacco Smoke on Rat Testis

机译：无烟烟草和烟草烟雾亚急性暴露对大鼠睾丸影响的比较评估

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This study investigated the effects of 30-day exposure to tobacco smoke (TS), smokeless tobacco (ST), and nicotine on reproductive parameters and oxidative biomarkers in prepubertal and adult male rats. Sperm motility was reduced by 77.5 and 89.0% in TS and ST exposed prepubertal rats and 71.1 and 86.4% in adult rats, respectively. Sperm count was also reduced by 64.7 and 89.9% in prepubertal rats and 64.9 and 47.0% in adult rats, respectively. Nicotine decreased sperm motility (82.2%) and count (62.6%) in prepubertal rats but caused no effect in adult rats. There were no changes in sperm morphology; testosterone was decreased, while LH and FSH were increased in exposed rats, when compared with control. Malondialdehyde levels in testes of exposed rats were increased, and GSH, SOD, and catalase were altered. Results indicate that subacute exposure of tobacco products alters sperm characteristics in a rank order of ST > TS > nicotine, which may be linked to increase in oxidative stress in the testis.
机译：这项研究调查了暴露于烟草烟雾（TS），无烟烟草（ST）和尼古丁30天对青春期前和成年雄性大鼠生殖参数和氧化生物标记物的影响。 TS和ST暴露的青春期前大鼠精子活力分别降低77.5％和89.0％，成年大鼠精子活力分别降低71.1％和86.4％。青春期前的精子数量也分别减少了64.7％和89.9％，成年大鼠的精子数量也减少了64.9％和47.0％。青春期前尼古丁降低了精子活力（82.2％）和计数（62.6％），但对成年大鼠没有影响。精子形态没有变化。与对照组相比，暴露的大鼠睾丸激素降低，而LH和FSH升高。暴露大鼠睾丸中丙二醛水平升高，GSH，SOD和过氧化氢酶发生改变。结果表明，烟草制品的亚急性暴露会按照ST> TS>尼古丁的等级顺序改变精子的特性，这可能与睾丸氧化应激的增加有关。

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