...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Medicine and Medical Sciences >Significance of IL28B Gene Polymorphism in the Prediction of Clinical Outcomes of Viral Hepatitis Leading to Liver Cirrhosis
【24h】

Significance of IL28B Gene Polymorphism in the Prediction of Clinical Outcomes of Viral Hepatitis Leading to Liver Cirrhosis

机译：IL28B基因多态性在预测导致肝硬化的病毒性肝炎临床结果中的意义

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Conducted numerous studies about viral hepatitis outcome showed that in most cases the disease proceeds with the formation of liver cirrhosis. The exact mechanisms leading to the development of an unfavorable disease outcome are unknown. A research is conducted for revealing factors that leads chronic viral hepatitis to liver cirrhosis. In recent years, the role of genetic determinants is studied thoroughly to develop systemic diseases regarding liver cirrhosis. There is a need to evaluate the significance of genes polymorphisms in the predictions of the clinical outcome of hepatitis B, D and C. The aim of our study was to investigate the influence of genetic variation of IL28B gene on the risk of developing liver cirrhosis as well as the possibility of disease outcome prognosis of HBV, HDV, HCV infected patients. This article provides information about the influence of IL28B gene polymorphisms on the outcomes of chronic viral hepatitis. The study of genetic markers that influence the formation of liver cirrhosis with HBV, HDV, HCV infection, will allow creating a methodical approach to an individualized assessment of the risk of formation of an unfavorable disease outcome. The presented calculations statistically confirm the evidence that certain alleles of IL28B gene, as well as their adverse combinations have significant differences between the groups of patients with viral hepatitis of various etiologies. Thus, the genetic analysis is a promising method for non-invasive diagnosis of liver cirrhosis risk.
机译：关于病毒性肝炎结局进行的大量研究表明，在大多数情况下，疾病会随着肝硬化的形成而发展。导致不良疾病结果发生的确切机制尚不清楚。进行了一项研究，以揭示导致慢性病毒性肝炎导致肝硬化的因素。近年来，对遗传决定因素的作用进行了深入研究，以发展有关肝硬化的系统性疾病。有必要评估基因多态性在预测乙型，丁型和丙型肝炎临床预后中的意义。我们的研究目的是研究IL28B基因的遗传变异对肝硬化发生风险的影响。以及HBV，HDV，HCV感染患者疾病预后的可能性。本文提供有关IL28B基因多态性对慢性病毒性肝炎预后的影响的信息。对影响HBV，HDV，HCV感染肝硬化形成的遗传标志物的研究，将为建立个体化评估不良疾病结局风险的方法提供一种有条理的方法。提出的计算从统计学上证实了以下证据：IL28B基因的某些等位基因及其不良组合在各种病因的病毒性肝炎患者组之间具有显着差异。因此，遗传分析是非侵入性诊断肝硬化风险的一种有前途的方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号