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首页> 外文期刊>American journal of men’s health. >Prevalence of Relative Deficiencies in Testosterone and Vitamin B12 Among Patients Referred for Chronic Orchialgia: Implications for Management
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Prevalence of Relative Deficiencies in Testosterone and Vitamin B12 Among Patients Referred for Chronic Orchialgia: Implications for Management

机译：慢性睾丸痛患者中睾丸激素和维生素B12相对缺乏症的患病率：对管理的意义

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Chronic testicular pain (CTP) is a complex pain syndrome that is widely variable in presentation and etiology. Many cases of CTP are thought to be associated with neuropathy and recent data suggest an inflammation-mediated process is more common among patients with CTP. Deficiencies in vitamin B12 and testosterone are common in chronic pain syndromes may play a role in CTP. A retrospective review of men treated for CTP by a single provider over a 2-year period was performed. Patients with serum screening of testosterone and B12 were selected. Patients with total testosterone below 300 ng/dl, free testosterone below 46 pg/ml, or B12 below 400 pg/ml were deemed deficient and offered repletion. Efficacy of treatment was measured based on patient report with a minimum follow-up of either 3 months or resolution of pain symptoms. One hundred and fifty-four (154) men with CTP were identified, with 125 assessed for testosterone and B12 levels. Of these, 95 patients (76%) were deemed deficient. Fifty-six (56) patients elected to receive B12/testosterone replacement. In patients with sufficient follow-up, 24 patients (65%) reported significant improvement of symptoms, 6 patients (16%) reported some improvement, and 7 patients (19%) reported no improvement. The prevalence of testosterone and B12 deficiencies in this study is much higher than that reported for the general population. In addition, when chemical deficiencies were corrected, greater than 80% of patients with sufficient follow-up reported some improvement in pain. This suggests that screening of B12 and testosterone should be incorporated into the assessment of patients with CTP.
机译：慢性睾丸疼痛（CTP）是一种复杂的疼痛综合征，在表现和病因上差异很大。许多CTP病例被认为与神经病变有关，最近的数据表明，炎症介导的过程在CTP患者中更为普遍。维生素B12和睾丸激素缺乏症在慢性疼痛综合征中很常见，可能在CTP中起作用。回顾性回顾了由单一提供者在2年内接受过CTP治疗的男性。选择进行睾丸激素和B12血清筛查的患者。总睾丸激素低于300 ng / dl，游离睾丸激素低于46 pg / ml或B12低于400 pg / ml的患者被认为是缺乏的，并且可以补充。根据患者报告评估治疗效果，至少随访3个月或缓解疼痛症状。确定了一百四十四名（154名）CTP男性，其中125名评估了睾丸激素和B12水平。其中，有95名患者（占76％）被认为是缺陷患者。五十六（56）名患者选择接受B12 /睾丸激素替代。在进行了充分随访的患者中，有24例（65％）的症状明显改善，有6例（16％）的症状有所改善，有7例（19％）的症状没有改善。这项研究中睾丸激素和B12缺乏症的患病率比一般人群的患病率高得多。此外，如果纠正了化学缺陷，则在进行充分随访的患者中，超过80％的患者表示疼痛有所改善。这表明对CTP患者的评估应包括对B12和睾丸激素的筛查。

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