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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Comparison of intravenous hydralazine and intravenous labetalol in the management of severe hypertensive disorders of pregnancy: a tertiary care centre study
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Comparison of intravenous hydralazine and intravenous labetalol in the management of severe hypertensive disorders of pregnancy: a tertiary care centre study

机译：静脉注射肼屈嗪和静脉注射拉贝洛尔治疗严重高血压疾病的比较：三级护理中心研究

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Background: Severe hypertension in pregnancy (SBP ≥160 mmHg &/or DBP ≥ 110 mmHg) must be treated judiciously to prevent maternal and fetal complications. The study was conducted to compare the efficacy, adverse effects, maternal and fetal outcome between Hydralazine and Labetalol which are the most commonly used drugs for the purpose. Methods: In a prospective study, 130 pregnant patients each with severe hypertension presenting to SMGS Hospital Jammu were randomized in 2 groups and administered hydralazine or labetalol intravenously. The efficacy of the two drugs was measured in terms of number of doses required to obtain target BP and the timing to achieve the same. The incidence of adverse effects, maternal and fetal outcomes were also compared. Comparisons among the two groups was performed by using independent Student’s t test for normally distributed variables, Fishers’ exact test, and Pearson Chi Square test for categorical variables. The level of significance was set at p0.05 for all analysis. Results: There was no statistical difference between the two drugs in terms of efficacy. Significantly more low-birth weight infants were born in the hydralazine group. Also, the adverse effects were significantly more in the hydralazine group. Conclusions: Both hydralazine and labetalol can be used to treat hypertensive emergencies of pregnancy but hydralazine is associated with more side effects.
机译：背景：妊娠期间的严重高血压（SBP≥160mmHg和/或DBP≥110 mmHg）必须谨慎治疗，以防止母婴并发症。这项研究是为了比较肼屈嗪和拉贝洛尔之间的疗效，不良反应，母体和胎儿结局，这两种药物是最常用的药物。方法：在一项前瞻性研究中，将SMGS医院查mu分校的130例重度高血压妊娠孕妇随机分为两组，并静脉注射肼苯哒嗪或拉贝洛尔。根据获得目标BP所需的剂量数和达到目标BP的时机来衡量这两种药物的功效。还比较了不良反应，母婴结局的发生率。两组之间的比较是通过对正态分布变量使用独立的Student t检验，Fishers精确检验和对分类变量使用Pearson Chi Square检验进行的。所有分析的显着性水平均设置为p <0.05。结果：两种药物在疗效方面无统计学差异。肼屈嗪组出生的低出生体重儿明显多。此外，肼苯哒嗪组的不良反应明显更多。结论：肼屈嗪和拉贝洛尔均可用于治疗妊娠高血压急症，但肼屈嗪具有更多的副作用。

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