...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Dental Research >Iodine release and antibacterial effects of a wound paste combined with PVP-iodine powder and/or solution in vitro
【24h】

Iodine release and antibacterial effects of a wound paste combined with PVP-iodine powder and/or solution in vitro

机译：伤口糊与PVP-碘粉和/或溶液的体外碘释放和抗菌作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Improvements of the substantivity of antibacterial agents in periodontal pockets during active therapy is still a challenge. With this study, the release kinetics of PVP-iodine by simply creating mixtures of a PVP-iodine solution and powder incorporated in different concentrations into a commercially available wound paste was investigated. It was postulated that this approach could result in an extended iodine release of at least one hour resulting in adequate antibacterial concentrations. Methods: Iodine concentrations released by different formulations were determined by a titration method and the antibacterial effect was investigated using an agar diffusion method assessing the inhibition zone of two representative periopathogenic bacteria (Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis) . Results: A prolonged release kinetic with up to one third of iodine released after one hour and even an ongoing release up to 4 hours was shown. The cumulative concentrations in the immersion solutions were sufficiently high to effectively inhibit bacterial growth in the agar test. The pH of the different mixtures was adequately buffered when tested in SBF as immersion medium, but resulted in acidic conditions when water was used. Conclusions: Simple mixing of PVP-powder to an available wound paste may offer an easy method to prepare antibacterial products in-office with a potential pocket disinfection duration during the scaling and root planning appointment. Nevertheless, its therapeutic usefulness under clinical conditions needs further investigation and potential side-effects require clarification.
机译：背景：积极治疗期间如何改善牙周袋中抗菌剂的直接性仍然是一个挑战。通过这项研究，研究了通过简单地创建PVP碘溶液和以不同浓度掺入市售伤口糊剂中的粉末的混合物来释放PVP碘的动力学。据推测，该方法可能导致碘释放延长至少一小时，从而导致足够的抗菌浓度。方法：通过滴定法测定由不同制剂释放的碘浓度，并通过琼脂扩散法研究抗菌作用，以评估两种代表性的致病性细菌（聚集放线菌和牙龈卟啉单胞菌）的抑制区。结果：显示出延长的释放动力学，一小时后释放出多达三分之一的碘，甚至持续释放到长达4小时。浸液中的累积浓度足够高，可以在琼脂试验中有效抑制细菌的生长。当在SBF中作为浸没介质进行测试时，不同混合物的pH值得到了足够的缓冲，但是当使用水时会导致酸性条件。结论：将PVP粉末与可用的伤口糊剂简单混合可提供一种简便的方法，以在办公室制备抗菌产品，并在洗牙和进行根部规划期间可能会进行口袋消毒。然而，其在临床条件下的治疗有用性需要进一步研究，潜在的副作用需要澄清。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号