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首页> 外文期刊>American Journal of Microbiological Research >Comparative Antimicrobial Effectiveness of Two Medicated Soaps with Herbal Soap from Morinda morindoides (Rubiaceae) against Skin Pathogens
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Comparative Antimicrobial Effectiveness of Two Medicated Soaps with Herbal Soap from Morinda morindoides (Rubiaceae) against Skin Pathogens

机译：两种药用皂与巴戟天的草药皂对皮肤病原菌的比较抗菌效果

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摘要

In present study two medicated soaps namely Pharmaderm and Micoderme and herbal soap Morinda formulated with fat extracted from leaves of Morinda morindoides (Rubiaceae) were investigated for their antimicrobial activities against some clinical strains for skin.diseases. The purpose of this study was to verify and compare their antimicrobial effectiveness. Agar broth dilution method with Sabouraud and Mueller-Hinton at serial concentrations of soaps ranging from 62.50 to 3.9 mg/ml and agar plate method were used to determine antimicrobial parameters. All strains tested were inhibited significantly (p < 0.05) by different types of soaps with minimal fungicidal concentration (MFC) ranging from 62.50 - 7.81 mg/ml and minimal bactericidal concentration (MBC) between 31.25 – 7.81 mg/ml. Soap Micoderme exhibited highest antimicrobial effectiveness with MFC varying from 7.81 to 31.25 mg/ml and MBC of 15.62 mg/ml. Soaps Morinda and Pharmaderm showed similar antibacterial activities with MBC of 31.25 mg/ml. Soap Morinda with MFC of 31.25 mg/ml was more effectiveness than soap Pharmaderm (MFC of 62.50 mg/ml) against all fungi. T. mentagrophytes was most sensitive fungi whereas C. albicans was least strain in presence of tested soaps. S. aureus was the most resistant among testing bacteria. This study demonstrated that hence buttressing the information written on two medicated soaps labels they possess antimicrobial activity and fat of M. morindoides incorporated at 10 % on basic soap formulation gave an effective antimicrobial power to soap Morinda. Further investigation was to clarify the phytochemical groups of herbal fat responsible for antimicrobial power of soap Morinda.
机译：在本研究中，研究了两种药用皂，分别是Pharmaderm和Micoderme，以及用从Morinda morindoides（茜草科）的叶子中提取的脂肪配制而成的草本皂Morinda对某些临床皮肤病菌的抗菌活性。这项研究的目的是验证和比较其抗菌效果。使用Sabouraud和Mueller-Hinton在一系列肥皂浓度为62.50至3.9 mg / ml的琼脂肉汤稀释法和琼脂平板法确定抗微生物参数。所有测试菌株均受到不同类型肥皂的显着抑制（p <0.05），其最低杀菌浓度（MFC）为62.50-7.81 mg / ml，最低杀菌浓度（MBC）为31.25 – 7.81 mg / ml。 Soap Micoderme表现出最高的抗菌效果，其中MFC从7.81到31.25 mg / ml不等，MBC为15.62 mg / ml。香皂Morinda和Pharmaderm表现出相似的抗菌活性，MBC为31.25 mg / ml。含有31.25 mg / ml MFC的巴戟天皂比针对所有真菌的Pharmaderm皂（62.50 mg / ml MFC）更有效。在测试肥皂的存在下，棉铃虫是最敏感的真菌，而白色念珠菌的菌株最少。金黄色葡萄球菌是测试细菌中最有抵抗力的。这项研究表明，因此支持在两种药用肥皂标签上书写的信息，它们具有抗菌活性，而在基本肥皂配方中掺入10％的莫林多脂的脂肪赋予了肥皂皂有效的抗菌力。进一步的研究是弄清负责肥皂巴戟天抗菌能力的草药脂肪的植物化学基团。

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