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首页> 外文期刊>International Journal of Nanomedicine >Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule
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Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule

机译：纳米结构脂质载体负载的透明质酸微针，用于控制亲脂分子的真皮递送

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Abstract: Nanostructured lipid carriers (NLCs) were employed to formulate a lipophilic drug into hydrophilic polymeric microneedles (MNs). Hyaluronic acid (HA) was selected as a hydrophilic and bioerodible polymer to fabricate MNs, and nile red (NR) was used as a model lipophilic molecule. NR-loaded NLCs were consolidated into the HA-based MNs to prepare NLC-loaded MNs (NLC-MNs). A dispersion of NLCs was prepared by high-pressure homogenization after dissolving NR in Labrafil and mixing with melted Compritol, resulting in 268 nm NLCs with a polydispersity index of 0.273. The NLC dispersion showed a controlled release of NR over 24 hours, following Hixson–Crowell's cube root law. After mixing the NLC dispersion with the HA solution, the drawing lithography method was used to fabricate NLC-MNs. The length, base diameter, and tip diameter of the NLC-MNs were approximately 350, 380, and 30 μm, respectively. Fluorescence microscopic imaging of the NLC-MNs helped confirm that the NR-loaded NLCs were distributed evenly throughout the MNs. In a skin permeation study performed using a Franz diffusion cell with minipig dorsal skin, approximately 70% of NR was localized in the skin after 24-hour application of NLC-MNs. Confocal laser scanning microscopy (z-series) of the skin at different depths showed strong fluorescence intensity in the epidermal layer, which appeared to spread out radially with the passage of time. This study indicated that incorporation of drug-loaded NLCs into MNs could represent a promising strategy for controlled dermal delivery of lipophilic drugs.
机译：摘要：采用纳米结构脂质载体（NLCs）将亲脂性药物制成亲水性聚合物微针（MNs）。选择透明质酸（HA）作为亲水性和可生物侵蚀的聚合物来制造MN，并使用尼罗红（NR）作为模型亲脂性分子。将加载了NR的NLC合并到基于HA的MN中，以准备加载了NLC的MN（NLC-MN）。在将NR溶解在Labrafil中并与熔融的Compritol混合后，通过高压均质化制备NLC的分散体，得到268nm的NLC，其多分散指数为0.273。遵循希克森-克罗威尔立方根定律，NLC分散液在24小时内显示出NR的受控释放。将NLC分散液与HA溶液混合后，使用拉延光刻法制造NLC-MN。 NLC-MN的长度，基本直径和尖端直径分别约为350、380和30μm。 NLC-MNs的荧光显微成像有助于确认装载NR的NLCs在整个MNs中均匀分布。在使用Franz扩散池和小猪背侧皮肤进行的皮肤渗透研究中，应用NLC-MN 24小时后，大约70％的NR定位在皮肤中。在不同深度的皮肤的共聚焦激光扫描显微镜（z系列）显示，表皮层中的荧光强度很强，并随着时间的流逝呈放射状扩散。这项研究表明，将载有药物的NLC掺入MN中，可以代表一种控制亲脂性药物通过皮肤递送的有前途的策略。

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