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首页> 外文期刊>International Journal of Nanomedicine >Evaluation of highly carbonated hydroxyapatite bioceramic implant coatings with hierarchical micro-anorod topography optimized for osseointegration
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Evaluation of highly carbonated hydroxyapatite bioceramic implant coatings with hierarchical micro-anorod topography optimized for osseointegration

机译：通过针对骨整合优化的分层微/纳诺德形貌评估高度碳酸化的羟基磷灰石生物陶瓷植入物涂层

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Background: Optimal osseointegration has been recognized as a pivotal factor in determining the long-term success of biomedical implants. Materials and methods: In the current study, highly carbonated hydroxyapatite (CHA) with carbonate contents of 8, 12 and 16 wt% and pure hydroxyapatite (HA) were fabricated via a novel hydrothermal method and deposited on the titanium substrates to generate corresponding CHA bioceramic coatings (designated as C8, C12 and C16, respectively) and HA bioceramic coatings (designated as C0). Results: C8, C12 and C16 were endowed with nanoscale, hierarchical hybrid micro-anoscale and microscale surface topographies with rod-like superstructures, respectively. Compared with C0, the micro-anotextured CHA bioceramic coatings (C8, C12 and C16) possessed excellent surface bioactivity and biocompatibility, as well as better wettability, which mediated improved protein adsorption, giving rise to simultaneous enhancement of a biological cascade of events of rat bone-marrow-derived mesenchymal stem cells including cell adhesion, proliferation, osteogenic differentiation and, notably, the production of the pro-angiogenic growth factor, vascular endothelial growth factor-A. In particular, C12 with biomimetic hierarchical hybrid micro-anorod topography exhibited superior fractal property and predominant performance of protein adsorption, cell adhesion, proliferation and osteogenesis concomitant with angiogenesis. Conclusion: All these results suggest that the 12 wt% CHA bioceramic coating with synergistic modification of surface chemistry and topography has great prospect for future use as implant coating to achieve optimum osseointegration for orthopedic and dental applications.
机译：背景：最佳骨整合被认为是决定生物医学植入物长期成功的关键因素。材料和方法：在当前的研究中，通过新颖的水热法制备了碳酸盐含量分别为8、12和16 wt％的高度碳酸化的羟基磷灰石（CHA）和纯的羟基磷灰石（HA），并将其沉积在钛基底上以生成相应的CHA生物陶瓷涂层（分别指定为C8，C12和C16）和HA生物陶瓷涂层（指定为C0）。结果：C8，C12和C16分别具有纳米级，分层混合的微/纳米级和具有杆状超结构的微尺度表面形貌。与C0相比，微/纳米结构CHA生物陶瓷涂层（C8，C12和C16）具有出色的表面生物活性和生物相容性，以及更好的润湿性，介导了蛋白质吸附的改善，从而同时增强了生物事件的级联。大鼠骨髓来源的间充质干细胞，包括细胞粘附，增殖，成骨分化，特别是促血管生成生长因子，血管内皮生长因子-A的产生。特别地，具有仿生分级混合微/纳诺德地形学的C12表现出优异的分形性质以及与血管生成伴随的蛋白质吸附，细胞粘附，增殖和成骨作用的主要性能。结论：所有这些结果表明，具有表面化学和表面形貌的协同修饰作用的12 wt％CHA生物陶瓷涂层在将来用作植入物涂层以实现骨科和牙科应用的最佳骨整合方面具有广阔的前景。

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