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首页> 外文期刊>RSC Advances >Gentamicin-loaded carbonated hydroxyapatite coatings with hierarchically porous structures: drug delivery properties, bactericidal properties and biocompatibility
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Gentamicin-loaded carbonated hydroxyapatite coatings with hierarchically porous structures: drug delivery properties, bactericidal properties and biocompatibility

机译：庆大霉素负载的碳酸羟基磷灰石涂层具有分层的多孔结构：药物传递特性，杀菌特性和生物相容性

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Carbonated hydroxyapatite coatings (CHACs) on titanium alloy substrates have been widely used as bone substitute materials. However, implant-associated infection becomes a serious problem in orthopedic surgery, leading to prolonged antimicrobial treatment, extensive bone debridement and failure of implants. Herein, gentamicin-loaded CHACs (Gent-CHACs) were fabricated according to the following steps: (i) the conversion of CHACs with hierarchically porous structures from calcium carbonate coatings (CCCs) by treatment with phosphate buffer solutions, and (ii) loading gentamicin into the CHACs. The main constituents in the CHACs were plate-like carbonated hydroxyapatite particles with a low crystallinity. Mesopores with a pore size of similar to 3.8 nm and macropores (or apertures) with an aperture size of similar to 1 mu m existed within and among the plates, respectively. The hierarchically porous structures made the CHACs possess good drug loading-release properties. The sustained release of gentamicin from the Gent-CHACs inhibited significant bacterial adhesion and prevented biofilm formation against S. epidermidis (ATCC35984). In vitro cell tests indicated that human bone marrow stromal cells (hBMSCs) had good cell adhesion, spreading and proliferation on the Gent-CHACs. Moreover, the released gentamicin from the Gent-CHACs had no toxic effects on the hBMSCs. The good biocompatibility, drug delivery properties and bactericidal properties of the Gent-CHACs suggest that they have great potential as bone substitute materials.
机译：钛合金基材上的碳酸羟基磷灰石涂层（CHAC）已被广泛用作骨替代材料。然而，与植入物有关的感染在整形外科中成为一个严重的问题，导致延长的抗菌治疗，广泛的骨清创和植入物的失败。本文中，按照以下步骤制备了庆大霉素负载的CHAC（Gent-CHAC）：( i）通过磷酸盐缓冲溶液处理将碳酸钙涂层（CCC）中具有分层多孔结构的CHAC转化，以及（ii）负载庆大霉素进入CHAC。 CHAC中的主要成分是低结晶度的板状碳酸羟基磷灰石颗粒。在板之内和之中分别存在具有约3.8nm的孔径的中孔和具有约1μm的孔径的大孔（或孔）。分层多孔结构使CHAC具有良好的药物加载释放特性。庆大霉素从Gent-CHAC的持续释放抑制了细菌的显着粘附并阻止了针对表皮葡萄球菌（ATCC35984）的生物膜形成。体外细胞测试表明，人骨髓基质细胞（hBMSC）在Gent-CHAC上具有良好的细胞粘附，扩散和增殖。此外，从Gent-CHAC中释放出的庆大霉素对hBMSC没有毒性作用。 Gent-CHAC的良好生物相容性，药物传递特性和杀菌特性表明，它们具有作为骨替代材料的巨大潜力。

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