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首页> 外文期刊>International Journal of Pharmacy and Pharmaceutical Sciences >IDENTIFICATION OF SILDENAFIL CITRATE AS AN ADULTERANT IN HERBAL PRODUCTS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH PHOTODIODE ARRAY DETECTOR
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IDENTIFICATION OF SILDENAFIL CITRATE AS AN ADULTERANT IN HERBAL PRODUCTS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH PHOTODIODE ARRAY DETECTOR

机译：高效液相色谱法与光电二极管阵列检测器鉴定柠檬酸西地那非作为草药中的添加剂

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Objective : Investigation of sildenafil citrate as an adulterant in the traditional liquid herbal products of the local market in Bangladesh. Methods: A reversed-phase high-performance liquid chromatographic (HPLC) method with photodiode array (PDA) detector system has been developed and validated for investigating the presence of synthetic phosphodiesterase 5 (PDE-5) enzyme inhibitor as an adulterant in the traditional herbal products. Nine of the liquid preparations (syrup), Balarista (A), Jinsant (B), Jernide (C), Bolarist (D), Sree Gopal Oil (E), Menostroge (F), Enerton (G), Ginseng (H) and Ginsin Plus (I), of six companies form local market of Bangladesh were investigated. Results: All the products (A–I) were found to contain sildenafil citrate as an adulterant. HPLC peak of the adulterant was confirmed by comparing retention time, UV spectra generated by PDA detector and peak spiking with the authentic sample of sildenafil citrate. The quantity of sildenafil citrate in A, B, C, D, E, F, G, H and I syrups were found to be 17, 22, 26, 25, 10, 24, 29, 22 and 17 mg/100 ml, respectively. Conclusion: The study indicated that all tested liquid herbal products contain sildenafil citrate as an adulterant. As PDE-5 inhibitors have severe side effects, possess drug-drug interaction and highly recommended to prescribe by registered physicians, the regulatory agency of Bangladesh should take necessary action to minimize the risk of patients.
机译：目的：调查孟加拉国当地市场上传统液体草药产品中枸of酸西地那非作为掺假剂的情况。方法：已开发了具有光电二极管阵列（PDA）检测器系统的反相高效液相色谱（HPLC）方法，并经过验证可用于研究合成草药中作为掺假剂的磷酸二酯酶5（PDE-5）酶抑制剂的存在。产品。九种液体制剂（糖浆），巴拉瑞斯塔（A），金森特（B），耶尼德（C），猪油（D），斯瑞·戈帕尔油（E），麦诺糖（F），埃纳顿（G），人参（H）对孟加拉国本地市场的六家公司的Ginsin Plus（I）进行了调查。结果：发现所有产品（A–I）均含有柠檬酸西地那非作为掺假品。通过比较保留时间，PDA检测器产生的UV光谱以及与枸with酸西地那非的真实样品的峰峰值，可以确认掺假品的HPLC峰。发现A，B，C，D，E，F，G，H和I糖浆中枸sil酸西地那非的含量分别为17、22、26、25、10、24、29、22和17 mg / 100 ml，分别。结论：研究表明，所有测试的液体草药产品都含有枸sil酸西地那非作为掺假品。由于PDE-5抑制剂具有严重的副作用，具有药物与药物的相互作用，并强烈建议由注册医生开具处方，因此孟加拉国的监管机构应采取必要的措施，将患者的风险降至最低。

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