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首页> 外文期刊>International Journal of Tissue Engineering >In VivoEvaluation of a Decellularized Limbal Graft for Limbal Reconstruction
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In VivoEvaluation of a Decellularized Limbal Graft for Limbal Reconstruction

机译：脱细胞的肢体移植重建肢体的体内评价

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摘要

Corneal and limbal epithelial function is highly dependent on its underlying matrix. In this study, we report thein vitroandin vivoeffects of a decellularized limbal matrix on corneal and limbal epithelial differentiation and repair. We demonstrate that a limbal matrix helps to maintain epithelial cells in a more proliferative and less differentiated state. We introduce a novel focal injury model to the limbus using an excimer laser and further show that transplanting a decellularized limbal graft after the limbal injury helps to promote epithelialization and reduce corneal haze formation. These results suggest that a decellularized limbal graft may be therapeutically beneficial in clinical cases of focal limbal deficiency.
机译：角膜和角膜缘上皮功能高度依赖于其基础基质。在这项研究中，我们报告了脱细胞的角膜缘基质对角膜和角膜缘上皮细胞的分化和修复的体外和体内作用。我们证明角膜缘基质有助于维持上皮细胞处于增生和分化程度较低的状态。我们使用准分子激光将新的局灶性损伤模型引入角膜缘，并进一步证明角膜缘损伤后移植脱细胞的角膜缘移植物有助于促进上皮形成并减少角膜混浊的形成。这些结果表明，脱细胞的角膜缘移植物在局灶性角膜缘缺损的临床病例中可能在治疗上有益。

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