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首页> 外文期刊>International Journal of Tissue Engineering >Alignment of Skeletal Muscle Cells Cultured in Collagen Gel by Mechanical and Electrical Stimulation
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Alignment of Skeletal Muscle Cells Cultured in Collagen Gel by Mechanical and Electrical Stimulation

机译：通过机械和电刺激在胶原蛋白凝胶中培养的骨骼肌细胞的排列

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For in vitro tissue engineering of skeletal muscle, alignment and fusion of the cultured skeletal muscle cells are required. Although the successful alignment of skeletal muscle cells cultured in collagen gel has been reported using a mechanical force, other means of aligning cultured skeletal muscle cells have not been described. However, skeletal muscle cells cultured in a two-dimensional dish have been reported to align in a uniform direction when electrically stimulated. The purpose of this study is to determine if skeletal muscle cells cultured three-dimensionally in collagen gels can be aligned by an electrical load. By adding direct current to cells of the C2C12 skeletal muscle cell line cultured in collagen gel, it was possible to align C2C12 cells in a similar direction. However, the ratio of alignment was better when mechanical force was used as the means of alignment. Thus for tissue engineering of skeletal muscle cells, electrical stimulation may be useful as a supplementary method.
机译：对于骨骼肌的体外组织工程，需要对培养的骨骼肌细胞进行排列和融合。尽管已经报道了使用机械力成功地对胶原蛋白凝胶中培养的骨骼肌细胞进行了对齐，但是还没有描述对齐对齐的骨骼肌细胞的其他方法。然而，据报道，在二维培养皿中培养的骨骼肌细胞在受到电刺激时会沿一致的方向排列。这项研究的目的是确定在胶原凝胶中三维培养的骨骼肌细胞是否可以通过电负载对齐。通过向胶原蛋白凝胶中培养的C2C12骨骼肌细胞系的细胞添加直流电，可以使C2C12细胞在相似方向上排列。但是，当使用机械力作为对准手段时，对准比更好。因此，对于骨骼肌细胞的组织工程，电刺激可以用作补充方法。

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