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首页> 外文期刊>Intestinal research. >Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review
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Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review

机译：粪便钙卫蛋白是否能同等准确地测量小肠和大肠克罗恩病的疾病活动？：系统综述

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Fecal calprotectin (FC) is a highly sensitive disease activity biomarker in inflammatory bowel disease. However, there are conflicting reports on whether the diagnostic accuracy in Crohn’s disease is influenced by disease location. The aim of this study was to undertake a systematic review of the published literature. Relevant databases were searched from inception to November 8, 2016 for cohort and case control studies which had data on FC in patients with isolated small bowel (SB) and large bowel (LB) Crohn’s disease. Reference standards for disease activity were endoscopy, magnetic resonance imaging, computed tomography or a combination of these. The QUADAS-2 research tool was used to assess the risk of bias. There were 5,619 records identified at initial search. The 2,098 duplicates were removed and 3,521 records screened. Sixty-one full text articles were assessed for eligibility and 16 studies were included in the final review with sensitivities and specificities per disease location available from 8 studies. Sensitivities of FC at SB and LB locations ranged from 42.9% to 100% and 66.7% to 100% respectively while corresponding specificities were 50% to 100% and 28.6% to 100% respectively. The sensitivities and specificities of FC to accurately measure disease activity in Crohn’s disease at different disease locations are diverse and no firm conclusion can be made. Better studies need to be undertaken to categorically answer the effect of disease location on the diagnostic accuracy of FC.
机译：粪钙卫蛋白（FC）是炎性肠病中高度敏感的疾病活动生物标志物。但是，关于克罗恩病的诊断准确性是否受疾病位置影响的报道存在矛盾。这项研究的目的是对公开发表的文献进行系统的回顾。从开始到2016年11月8日，在相关数据库中进行了队列研究和病例对照研究，这些研究包含了孤立性小肠（SB）和大肠（LB）克罗恩病患者FC的数据。疾病活动的参考标准是内窥镜检查，磁共振成像，计算机断层扫描或这些的组合。 QUADAS-2研究工具用于评估偏倚风险。最初搜索时发现了5,619条记录。删除了2,098个重复项，并筛选了3,521条记录。评估了61篇全文文章的资格，最终审查中纳入了16项研究，每项疾病的敏感性和特异性来自8项研究。 SB和LB位置的FC敏感性分别为42.9％至100％和66.7％至100％，而相应的特异性分别为50％至100％和28.6％至100％。 FC在不同疾病位置准确测量克罗恩病疾病活动的敏感性和特异性各不相同，无法得出确切结论。需要进行更好的研究以明确回答疾病位置对FC诊断准确性的影响。

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