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首页> 外文期刊>Intestinal research. >Symptomatic improvement with gluten restriction in irritable bowel syndrome: a prospective, randomized, double blinded placebo controlled trial
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Symptomatic improvement with gluten restriction in irritable bowel syndrome: a prospective, randomized, double blinded placebo controlled trial

机译：肠易激综合症中用面筋限制的症状改善：一项前瞻性，随机，双盲安慰剂对照试验

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Background/Aims The existence of non-celiac gluten sensitivity has been debated. Indeed, the intestinal and extra-intestinal symptoms of many patients with irritable bowel syndrome (IBS) but without celiac disease or wheat allergy have been shown to improve on a gluten-free diet. Therefore, this study set out to evaluate the effects of gluten on IBS symptoms. Methods We performed a double-blind randomized placebo-controlled rechallenge trial in a tertiary care hospital with IBS patients who fulfilled the Rome III criteria. Patients with celiac disease and wheat allergy were appropriately excluded. The participants were administered a gluten-free diet for 4 weeks and were asked to complete a symptom-based questionnaire to assess their overall symptoms, abdominal pain, bloating, wind, and tiredness on the visual analog scale (0-100) at the baseline and every week thereafter. The participants who showed improvement were randomly assigned to one of two groups to receive either a placebo (gluten-free breads) or gluten (whole cereal breads) as a rechallenge for the next 4 weeks. Results In line with the protocol analysis, 60 patients completed the study. The overall symptom score on the visual analog scale was significantly different between the two groups ( P Conclusions A gluten diet may worsen the symptoms of IBS patients. Therefore, some form of gluten sensitivity other than celiac disease exists in some of them, and patients with IBS may benefit from gluten restrictions.
机译：背景/目的已经讨论了非芹菜麸质敏感性的存在。确实，许多无麸质饮食的肠道和肠外症状已被证实可改善肠易激综合症（IBS）但无腹腔疾病或小麦过敏的患者。因此，本研究着手评估面筋对IBS症状的影响。方法我们在一家三级护理医院对符合Rome III标准的IBS患者进行了一项双盲，随机安慰剂对照再挑战试验。患有腹腔疾病和小麦过敏的患者被适当排除。参与者接受了无麸质饮食4周，并要求他们完成基于症状的问卷调查，以基线时的视觉模拟量表（0-100）评估其总体症状，腹痛，腹胀，风和疲倦以及此后的每周。表现有所改善的参与者被随机分配到两组中的一组，在接下来的4周内接受安慰剂（无麸质面包）或麸质（全谷类面包）作为挑战。结果根据方案分析，有60位患者完成了研究。视觉模拟量表的总体症状评分在两组之间存在显着差异（P结论麸质饮食可能会使IBS患者的症状恶化。因此，其中一些形式的麸质敏感性除了乳糜泻以外还存在，并且IBS可能受益于面筋限制。

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