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首页> 外文期刊>Intestinal research. >Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease
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Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease

机译：三种不同粪便钙卫蛋白检测在炎性肠病诊断中的准确性

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Background/Aims Several studies have found that the measurement of fecal calprotectin is useful for the early diagnosis of inflammatory bowel disease (IBD). We compared the effectiveness of three different fecal calprotectin kits for initial diagnosis in patients with suspected IBD. Methods We enrolled 31 patients with IBD (18 Crohn's disease [CD], 11 ulcerative colitis [UC], and two intestinal Beh?et's disease), five with irritable bowel syndrome (IBS), and five with other colitis (four infectious colitis and one intestinal tuberculosis). Diagnosis was based on clinical, laboratory, and endoscopic examinations. Fecal samples were obtained at the first diagnosis and calprotectin levels were measured using three different kits (Quantum Blue? Calprotectin, EliA? Calprotectin, and RIDASCREEN? Calprotectin). Results The overall accuracy for differentiating IBD from IBS or other colitis was 94% and 91%, respectively, for Quantum Blue? (cutoff, 50 μg/g); 92% and 89%, respectively, for EliA? (cutoff, 50 μg/g); and 82% and 76%, respectively, for RIDASCREEN? (cutoff, 50 μg/g). In patients with CD, the results of Quantum Blue? Calprotectin and EliA? Calprotectin correlated significantly with levels of the Crohn's disease activity index (Spearman's rank correlation coefficient, r=0.66 and r=0.49, respectively). In patients with UC, the results of EliA? Calprotectin correlated significantly with the Mayo score (r=0.70). Conclusions Fecal calprotectin measurement is useful for the identification of IBD. The overall accuracies of the three fecal calprotectin kits are comparable.
机译：背景/目的几项研究发现，粪便钙卫蛋白的测定可用于炎症性肠病（IBD）的早期诊断。我们比较了三种不同粪便钙卫蛋白试剂盒在可疑IBD患者中进行初步诊断的有效性。方法我们招募了31例IBD患者（18例克罗恩病[CD]，11例溃疡性结肠炎[UC]和2例肠白塞氏病），5例肠易激综合征（IBS），5例其他结肠炎（4例感染性结肠炎和一肠结核）。诊断基于临床，实验室和内窥镜检查。在首次诊断时获得粪便样品，并使用三种不同的试剂盒（Quantum Blue™Calprotectin，EliA™Calprotectin和RIDASCREEN®Calprotectin）测量钙卫蛋白的水平。结果昆腾蓝将IBD与IBS或其他结肠炎区分开的总体准确度分别为94％和91％。 （临界值为50μg/ g）; EliA分别为92％和89％。 （临界值为50μg/ g）;和RIDASCREEN的分别为82％和76％？ （临界值为50μg/ g）。在CD患者中，Quantum Blue的结果如何？钙卫蛋白和EliA？钙卫蛋白与克罗恩氏病活动指数水平显着相关（斯皮尔曼等级相关系数分别为r = 0.66和r = 0.49）。在UC患者中，EliA的结果如何？钙卫蛋白与Mayo评分显着相关（r = 0.70）。结论粪便钙卫蛋白的测定可用于IBD的鉴定。三种粪便钙卫蛋白试剂盒的总体准确性可比。

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