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首页> 外文期刊>International Journal of Surgery Case Reports >Giant hepatocellular carcinoma with bone metastasis in a young adult, emerged from pigmented adenoma with beta-Catenin activation: A case report
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Giant hepatocellular carcinoma with bone metastasis in a young adult, emerged from pigmented adenoma with beta-Catenin activation: A case report

机译：伴有β-Catenin活化的色素腺瘤出现一名年轻成年人的巨骨转移性肝癌：一例

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Introduction: Hepatocellular carcinomas (HCC) that are very large in size are a very rare finding in young adult. The malignant transformation of a pigmented hepatocellular adenoma (HCA) with beta-Catenin activation is a possible cause for appearance of HCC. Presentation of case: We present the case of a 33-year-old male with a huge HCC with bone metastasis, emerged from pigmented HCA with beta-Catenin activation. As a two-stage surgical procedure, a left hepatectomy followed by a partial rib resection was performed. Discussion: Giant hepatocellular carcinomas mostly develop in non-cirrhotic livers and at time of diagnosis an extrahepatic spread occurs in up to 15%. In the present case, the progression from a benign HCA to malignant HCC was documented, as a unique finding. Surgical resection is the only curative treatment and was successfully performed in this case. Conclusion: Hepatobiliary surgery with resection of metastases is the treatment with best long-term survival for patients with huge HCC. Molecular characterization as well as pigmentation analysis is useful tools for risk assessment of HCA.
机译：简介：大型肝细胞癌（HCC）在年轻成年人中非常罕见。色素肝细胞腺瘤（HCA）伴随β-连环素激活的恶性转化可能是导致HCC出现的原因。病例介绍：我们介绍了一名33岁的男性，患有巨大的HCC并伴有骨转移，该病例来自具有β-Catenin活化的色素HCA。作为两阶段的外科手术，先行左肝切除，然后切除部分肋骨。讨论：巨大的肝细胞癌主要发生在非肝硬化的肝脏中，在诊断时，肝外扩散的发生率高达15％。在本例中，从良性HCA到恶性HCC的进展已有记录，这是一个独特发现。手术切除是唯一的治疗方法，在这种情况下已成功完成。结论：肝胆外科手术切除转移灶是巨大肝癌患者最佳的长期生存治疗方法。分子表征和色素沉着分析是评估HCA风险的有用工具。

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