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Classification of liver samples and a novel method for the diagnosis of localized nodular dysplasia, hepatocellular adenoma and hepatocellular carcinoma

机译:肝标本的分类和诊断结节性异型增生,肝细胞腺瘤和肝细胞癌的新方法

摘要

The present invention relates to the technical field of liver diseases, their classification and diagnosis. The present invention is based on in vitro measurement of gene expression profiles and analysis of expression profiles using algorithms calibrated with reference samples, further converting liver samples into one of subgroups G1-G6; Hepatocellular carcinoma (HCC) sample to be classified; focal nodule dysplasia (FNH) sample; further classified into HNF1A mutant HCA, inflammatory HCA, β-catenin mutant HCA or other HCA samples Novel methods for classifying hepatocellular adenoma (HCA) samples; and other benign liver samples. The present invention also provides a kit for classification of liver samples and a method of treating liver disease in a subject based on a preliminary classification of the subject's liver samples.
机译:本发明涉及肝脏疾病的技术领域,其分类和诊断。本发明基于基因表达谱的体外测量和使用参照样品校准的算法对表达谱进行分析,进一步将肝样品转化为G1-G6亚组之一。待分类的肝细胞癌(HCC)样品;局灶性结节异常增生(FNH)样本;进一步分类为HNF1A突变型HCA,炎性HCA,β-连环蛋白突变型HCA或其他HCA样品对肝细胞腺瘤(HCA)样品进行分类的新方法;和其他良性肝样本。本发明还提供了用于对肝脏样品进行分类的试剂盒和基于受试者的肝脏样品的初步分类来治疗受试者的肝脏疾病的方法。

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