Detecting individual ancestry in the human genome

Andreas Wollstein; Oscar Lao

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Detecting individual ancestry in the human genome

机译：检测人类基因组中的个体血统

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Detecting and quantifying the population substructure present in a sample of individuals are of main interest in the fields of genetic epidemiology, population genetics, and forensics among others. To date, several algorithms have been proposed for estimating the amount of genetic ancestry within an individual. In the present review, we introduce the most widely used methods in population genetics for detecting individual genetic ancestry. We further show, by means of simulations, the performance of popular algorithms for detecting individual ancestry in various controlled demographic scenarios. Finally, we provide some hints on how to interpret the results from these algorithms.

机译：检测和量化个体样本中存在的种群亚结构是遗传流行病学，种群遗传学和法医学等领域的主要兴趣。迄今为止，已经提出了几种算法来估计个体中遗传祖先的数量。在本文中，我们介绍了群体遗传学中检测个体遗传谱系最广泛使用的方法。通过仿真，我们进一步展示了在各种受控的人口统计情况下用于检测个人血统的流行算法的性能。最后，我们对如何解释这些算法的结果提供了一些提示。

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《Investigative Genetics》 |2015年第1期|共页
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Andreas Wollstein; Oscar Lao;
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中图分类遗传学;
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1. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium [J] . Maggie C. Y. Ng, Mariaelisa Graff, Yingchang Lu, PLoS Genetics . 2017,第4期

机译：在非洲血统的个体中使用全基因组关联研究的高密度插值发现和精确定位肥胖基因座：非洲祖先人体测量学遗传学联盟
2. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium [J] . Maggie C. Y. Ng, Mariaelisa Graff, Yingchang Lu, PLoS Genetics . 2017,第4期

机译：肥胖基因座的发现和精细映射利用非洲血统个体基因组关联研究的高密度归解：非洲血统人类学遗传联盟
3. A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans [J] . Need AC, Cirulli ET Genome Biology . 2009,第1期

机译：犹太人祖先的全基因组遗传特征可以完美地将大量具有和没有犹太人祖先的个体隔离在大量的美国人中
4. A New Approach for Using Genome Scans to Detect Recent Positive Selection in the Human Genome [C] . Kun Tang, Kevin R.Thornton, Mark Stoneking 中国科协第199次青年科学家论坛 . 2009

机译：使用基因组扫描检测人类基因组中最近阳性选择的新方法
5. Clustering by genetic ancestry using genome-wide single nucleotide polymorphisms and incorporating genetic ancestry into genetic risk prediction models. [D] . Solovieff, Nadia. 2011

机译：使用全基因组单核苷酸多态性通过遗传祖先进行聚类，并将遗传祖先纳入遗传风险预测模型。
6. Detecting individual ancestry in the human genome [O] . Andreas Wollstein, Oscar Lao 2015

机译：检测人类基因组中的个体血统
7. Detecting individual ancestry in the human genome [O] . 2015

机译：检测人类基因组中的个体血统

Detecting individual ancestry in the human genome

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