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Long-term RNA persistence in postmortem contexts

机译：死后环境中的长期RNA持久性

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摘要

Ribonucleic acids (RNA) are generally considered fragile molecules that are readily degraded. However, there is growing documentation of long-term (from days to centuries) RNA persistence in a variety of contexts and tissue types, and as such a number of academic disciplines are beginning to exploit degraded RNA. While the reasons for its survival are not fully understood, there are several plausible mechanisms that would safeguard this molecule against degradation. However, after examining the literature available on the postmortem instability and decay mechanisms of RNA, it has become clear that limited experimental studies and no reviews offer an overview of these mechanisms. Hence in this review we outline molecular reasons for RNA surviving long-term postmortem, and provide specific examples of RNA survival in forensic, archival and archaeological contexts. A better understanding of the mechanisms of RNA decay will be crucial for developing expectations on its long-term survival.
机译：核糖核酸（RNA）通常被认为是易降解的易碎分子。但是，越来越多的文献报道了在各种情况下和组织类型中长期（从几天到几个世纪）的RNA持久性，因此许多学术学科开始利用降解的RNA。尽管其存活的原因尚不完全清楚，但有几种可能的机制可以保护该分子免于降解。但是，在检查了有关RNA的事后不稳定性和衰变机制的文献之后，很明显，有限的实验研究且没有评论提供这些机制的概述。因此，在本综述中，我们概述了RNA长期死后存活的分子原因，并提供了法医，档案和考古背景下RNA存活的具体实例。更好地了解RNA衰变的机制对于发展对其长期存活的期望至关重要。

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