Comment on Kokshoorn, B, and Blankers, BJ ‘Response to Grisedale, KS and van Daal, A: comparison of STR profiling from low template DNA extracts with and without the consensus profiling method’

Kelly Grisedale; Angela van Daal

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Comment on Kokshoorn, B, and Blankers, BJ ‘Response to Grisedale, KS and van Daal, A: comparison of STR profiling from low template DNA extracts with and without the consensus profiling method’

机译：评论Bok，Kokshoorn和BJ的“对堪萨斯州Grisedale和Van Daal的回应：使用和不使用共有序列分析方法的低模板DNA提取物的STR谱比较”

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Kokshoorn and Blankers responded to our recent article by saying that replicate analysis and consensus profiling of low template samples was best in terms of reliability and objectivity. We agree that the consensus approach has benefits, particularly in eliminating non-repeating spurious alleles from the final profile. However, with the development of statistical models that can accommodate stochastic effects and allele drop in, it may be beneficial to perform a single amplification with three times the amount of template, since much information is lost from the profile using the consensus approach. Please see related article: http://www.investigativegenetics.com/content/4/1/1 webcite

机译：Kokshoorn和Blankers在回应我们最近的文章时说，就可靠性和客观性而言，对低模板样本进行重复分析和共识分析是最好的。我们同意共识方法具有好处，特别是在从最终特征中消除非重复性伪等位基因方面。但是，随着统计模型的发展，可以容纳随机效应和等位基因落入，使用三倍模板量进行单次扩增可能是有益的，因为使用共识方法会从配置文件中丢失大量信息。请参阅相关文章：http://www.investigativegenetics.com/content/4/1/1网站

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《Investigative Genetics》 |2013年第1期|共页
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Kelly Grisedale; Angela van Daal;
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1. Response to Grisedale and Van Daal: comparison of STR profiling from low template DNA extracts with and without the consensus profiling method [J] . Bas Kokshoorn, Bart J Blankers Investigative Genetics . 2013,第1期

机译：对Grisedale和Van Daal的响应：使用和不使用共有特征分析方法的低模板DNA提取物的STR特征分析的比较
2. Comparison of STR profiling from low template DNA extracts with and without the consensus profiling method [J] . Kelly S Grisedale, Angela van Daal Investigative Genetics . 2012,第1期

机译：有和没有共有分析方法的低模板DNA提取物中STR分析的比较
3. Automating a combined composite-consensus method to generate DNA profiles from low and high template mixture samples [J] . BekaertB., VanGeystelenA., VanderheydenN., Forensic science international. Genetics . 2012,第5期

机译：自动化组合共识方法，从低和高模板混合物样品生成DNA谱
4. Comment on Kokshoorn B and Blankers BJ ‘Response to Grisedale KS and van Daal A: comparison of STR profiling from low template DNA extracts with and without the consensus profiling method’ [O] . Kelly Grisedale, Angela van Daal 2013

机译：评论Bok的Kokshoorn和BJ的对堪萨斯州的Grisedale和Van Daal的回应：使用和不使用共有序列分析方法的低模板DNA提取物中STR谱的比较
5. Comment on Kokshoorn, B, and Blankers, BJ ‘Response to Grisedale, KS and van Daal, A: comparison of STR profiling from low template DNA extracts with and without the consensus profiling method’ [O] . 2013

机译：评论Bok的Kokshoorn和BJ的“对堪萨斯州的Grisedale和Van Daal的回应：使用和不使用共有序列分析方法的低模板DNA提取物中STR谱的比较”

Comment on Kokshoorn, B, and Blankers, BJ ‘Response to Grisedale, KS and van Daal, A: comparison of STR profiling from low template DNA extracts with and without the consensus profiling method’

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