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首页> 外文期刊>International Journal of Surgical Research >A Clinical Study of Combined Systemic Co-Amoxiclave and Metronidazole as Adjuncts to Periodontal Surgery in the Treatment of Advanced Periodontal Disease
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A Clinical Study of Combined Systemic Co-Amoxiclave and Metronidazole as Adjuncts to Periodontal Surgery in the Treatment of Advanced Periodontal Disease

机译：全身性阿莫西拉夫和甲硝唑联用辅助牙周手术治疗晚期牙周病的临床研究

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摘要

Mechanical surgical treatments of periodontal pockets are usually effective in arresting the progression of the disease .The aim of present investigation was to determine if the simultaneous administration of systemic amoxicillin, clavulanic acid and metronidazole as adjunct to periodontal pocket surgery.Fifty patients with advanced chronic periodontal lesions took part in this study of which 36 completed the study Only at the first surgical visit, the patients in test group received co-amoxiclav 625mg tablets tid for one week plus metronidazole 250mg tablets for one week. The control group received amoxicillin 500 mg capsules tid for one week. Before the first surgical visit, and 6 weeks after the last surgical visit, probing pocket depth, clinical attachment level and bleeding on probing were measured by a single examiner The difference between the probing pocket depth reductions of the 2 groups was not statistically significant (p=0.59). The difference between the attachment gains of the 2 groups was not statistically significant (p=0.58). The difference between BOP reductions of the 2 group was not significant (p=0.75).It was concluded from this study that the addition of clavulanic acid and metronidazole, provided no additional improvement beyond that could be achieved by periodontal surgical debridement plus amoxicillin.
机译：机械手术治疗牙周袋通常可以有效地阻止疾病的进展。本研究的目的是确定是否同时给予全身性阿莫西林，克拉维酸和甲硝唑作为牙周袋手术的辅助治疗。病变参与了这项研究，其中36项完成了研究。仅在第一次手术就诊时，测试组的患者接受了omodaxiclav 625mg每日两次tid的治疗，以及甲硝唑250mg一周的治疗。对照组接受阿莫西林500 mg胶囊tid治疗一周。第一次手术前和最后一次手术后6周，由一名检查员测量探查袋深度，临床附着水平和探查出血。两组的探查袋深度减少之间的差异无统计学意义（p = 0.59）。两组的依恋增益之间的差异无统计学意义（p = 0.58）。两组的BOP降低之间的差异不显着（p = 0.75）。从这项研究得出的结论是，添加克拉维酸和甲硝唑不能提供牙周外科清创术加阿莫西林所能达到的其他改善。

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