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首页> 外文期刊>Iranian journal of public health. >Interaction of Depression and Nicotine Addiction on the Severity of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study
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Interaction of Depression and Nicotine Addiction on the Severity of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study

机译：抑郁与尼古丁成瘾对慢性阻塞性肺疾病严重程度的相互作用：一项前瞻性队列研究

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Background: Depression and smoking decrease health status in Chronic Obstructive Pulmonary Disease (COPD), but the combined effect of the two factors is unknown. This study aimed to assess the interactive effects of depression and smoking on the severity of patients with COPD.Methods: A prospective cohort study including 2,268 patients with COPD was conducted in seven rural communities from May 2008 to May 2012. The relationships between the BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index and depression and nicotine addiction were assessed. The product of depression and smoking was added to the logistic regression model to evaluate the multiplicative interaction and relative excess risk of interaction (RERI). The Attributable Proportion (AP) of interaction and the synergy index (S) was applied to evaluate the additive interaction of two factors.Results: The severity of COPD in patients with depressive symptoms who never smoked was increased 1.74-fold and in smoking patients it increased by 6.08-fold. Highly addicted smokers with depressive symptoms had a nearly 40-fold increase in severity (all P<0.001). The increased values of the BODE index, HADS-D and Fagerstr?m score also correlated positively (P<0.001). The co-presence of depressive symptoms and smoking significantly increased the BODE index by 11.99-fold with significant biological interactions, relative excess risk of interaction (RERI) was 12.12, the biological interactions were increased with increasing nicotine addiction.Conclusions: Patients with depressive symptoms who also smoke have an increased risk of severity from COPD interaction effects. The risk for severity of COPD and depressive symptoms increased with increasing the severity of nicotine addiction.
机译：背景：抑郁和吸烟会降低慢性阻塞性肺疾病（COPD）的健康状况，但是这两个因素的综合作用尚不清楚。这项研究旨在评估抑郁和吸烟对COPD患者严重程度的互动影响。方法：从2008年5月至2012年5月，在七个农村社区进行了一项包括2268例COPD患者的前瞻性队列研究。评估了体重指数，气流阻塞，呼吸困难和运动能力指数以及抑郁和尼古丁成瘾。抑郁和吸烟的乘积被添加到逻辑回归模型中，以评估乘法相互作用和相对相对相互作用的风险（RERI）。应用相互作用的归属比例（AP）和协同指数（S）评估两个因素的累加相互作用。结果：从未吸烟的抑郁症状患者的COPD严重程度增加了1.74倍，吸烟的患者则增加了1.74倍增加了6.08倍。患有抑郁症状的高度上瘾的吸烟者的严重程度增加了近40倍（所有P <0.001）。 BODE指数，HADS-D和Fagerstr？m得分的增加值也呈正相关（P <0.001）。抑郁症状和吸烟并存会导致BODE指数显着增加11.99倍，并且具有明显的生物学相互作用，相对过度相互作用的风险（RERI）为12.12，生物学相互作用随着尼古丁成瘾的增加而增加。结论：抑郁症状患者谁也吸烟会增加COPD相互作用的严重性风险。 COPD严重程度和抑郁症状的风险随尼古丁成瘾严重程度的增加而增加。

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