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首页> 外文期刊>Journal of the American Medical Directors Association >Examining the Effects of Age on Health Outcomes of Chronic Obstructive Pulmonary Disease: Results From the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study and Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate Endpoints Cohorts
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Examining the Effects of Age on Health Outcomes of Chronic Obstructive Pulmonary Disease: Results From the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study and Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate Endpoints Cohorts

机译：检查年龄对慢性阻塞性肺病的健康结果的影响：慢性阻塞性肺病研究和慢性阻塞性肺病的遗传流行病学的结果纵向识别预测替代终点队列

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Abstract Rationale The prevalence of chronic obstructive pulmonary disease (COPD) and its associated comorbidities increase with age. However, little is understood about differences in the disease in patients over 65爕ears of age compared with younger patients. Objectives To determine disease characteristics of COPD and its impact in older patients compared with younger patients. Methods We examined baseline characteristics of patients with COPD (global obstructive lung disease stage IIIV) in 2 large cohorts: Genetic Epidemiology of COPD Study (COPDGene) and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). We compared demographics, indices of disease severity, prevalence of comorbidities, exacerbation frequency, and quality of life scores in patients e65爕ears of age vs patients Results In the COPDGene cohort, older patients (n??663) had more severe disease as measured by forced expiratory volume in 1爏econd (1.22 vs 1.52燣, P ?P ?P ?P ?P ?P ?P ??02), shorter 6- minute walk distance (360 vs 389爉, P ?P ??009) than younger patients (n??131). In adjusted analyses of both cohorts, older age was associated with decreased frequency of exacerbations [odds ratio??.52, 95% confidence interval (CI)??.430.64 in COPDGene, odds ratio??.79, 95% CI??.640.99 in ECLIPSE] and a better quality of life (lower St. Georges respiratory questionnaire score) (矤=?8.7, 95% CI??10.0 to?7.4 in COPDGene, 矤=?4.4, 95% CI??6.1 to?3.2 in ECLIPSE). Conclusions Despite greater severity of illness, older patients with COPD had better quality of life and reported fewer exacerbations than younger patients. Although this observation needs to be explored further, it may be related to the fact that older patients change their expectations and learn to adapt to their disease.
机译：摘要理由慢性阻塞性肺病（COPD）的患病率及其相关的合并症随着年龄的增长而增加。然而，与年轻患者相比，患者患者患者患者的差异很少。与较年轻的患者相比，目的是确定COPD疾病特征及其对老年患者的影响。方法我们检查了2个大队列中COPD（全球阻塞性肺病阶段IIV）患者的基线特征：COPD研究的遗传流行病学和纵向评价，以鉴定预测替代终点（Eclipse）。我们比较人口统计，疾病严重程度的指标，患者患者的患者患者患者的患者，加剧频率和生活质量评分，VS患者的耳朵导致COPDGENE队列，老年患者（N-663）测量更严重的疾病通过强制呼气量在1‰Econd（1.22 Vs 1.52，P？P？P？P？P？P？P ?? 02），步行6分钟距离（360 VS 389，P？P ?? 009 ）比较年轻的患者（n ?? 131）。在调整后的群组分析中，年龄较大的年龄与加重频率下降有关[赔率比吗？52,95％置信区间（CI）??。430.64在Copdgene中，赔率比。79,95％CI ?? .640.99在日食]和更好的生活质量（下乔治呼吸问卷评分）（矤=？8.7,95％CI ?? 10.0至？7.4在Copdgene中，矤=？4.4,95％CI？6.1至？3.2在Eclipse中）。结论尽管疾病的严重程度较严重，但COPD的老年患者具有更好的生活质量，并报告比较年轻的患者更少的恶化。虽然这种观察需要进一步探索，但它可能与年龄较大的患者改变他们的期望并学会适应他们的疾病的事实有关。

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