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首页> 外文期刊>Iranian Journal of Pathology >THE DIAGNOSTIC VALUE OF SERUM IGG-ANTIGLIADIN, IGA ANTI-ENDOMYSIAL AND IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODIES FOR PEDIATRIC CELIAC DISEASE
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THE DIAGNOSTIC VALUE OF SERUM IGG-ANTIGLIADIN, IGA ANTI-ENDOMYSIAL AND IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODIES FOR PEDIATRIC CELIAC DISEASE

机译：血清IGG-抗人鞭毛素，IGA抗内毒素和IGA抗组织葡萄糖转移酶抗体对小儿宫颈疾病的诊断价值。

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Background and Objective: Celiac disease is an autoimmune disorder, characterized by inflammation, villous atrophy, and crypt hyperplasia of the small bowel mucosa. In this study we considered and compared sensitivity and specificity of serological tests in patients with celiac disease.Materials and Methods: In this cross-sectional study we prospectively recruited children with suspected celiac disease. An intestinal biopsy specimen was obtained from all patients. Celiac disease diagnosed on the basis of histologic findings of Marsh classification. A serum sample was taken at the time of biopsy for serologic tests. Findings were analyzed using SPSS program, t-test, and chisquare tests.Results: Out of a total of 134 children in this study, seventy (52.21%) patients were boy and sixty four (47.8%) patients were girl. Celiac disease was diagnosed in 14 (10.4%) of the patients.In serologic tests, 11 patients (78.6%) were positive for antigliadin-Ab, 4 (28.6%) for anti tissuetransglutaminase Ab, and 9 (64.3%) for antiendomysial antibody. Sensitivity of antigliadin-Ab was 78.6% and its specificity was 95.9%. Sensitivity of anti tissue-transglutaminase Ab was 28% and its specificity was 95%. Sensitivity of antiendomysial Ab was 64% and its specificity was 96%.Conclusion: Positive serologic tests are supportive of the diagnosis in those with characteristic histopathologic changes on small intestinal biopsy. The best tests for this purpose are the IgA antiendomysial antibody or IgA anti tissue-transglutaminase, both of which are highly sensitive and specific.
机译：背景与目的：腹腔疾病是一种自身免疫性疾病，其特征是炎症，绒毛萎缩和小肠粘膜隐窝增生。在这项研究中，我们考虑并比较了腹腔疾病患者的血清学检测的敏感性和特异性。材料与方法：在这项横断面研究中，我们前瞻性地招募了怀疑患有腹腔疾病的儿童。从所有患者获得肠活检标本。乳糜泻是根据Marsh分类的组织学发现诊断的。活检时采集血清样本进行血清学检查。结果：使用本研究的SPSS程序，t检验和卡方检验对结果进行了分析。结果：在本研究的134名儿童中，有70名（52.21％）为男孩，而64名（47.8％）为女孩。 14例（10.4％）患者被诊断出患有腹腔疾病。血清学检查中，抗麦醇溶蛋白Ab阳性的11例（78.6％），抗组织转谷氨酰胺酶Ab阳性的4例（28.6％）和抗内胚层抗体的9例（64.3％）。 。抗麦醇溶蛋白Ab的敏感性为78.6％，特异性为95.9％。抗组织转谷氨酰胺酶抗体的敏感性为28％，特异性为95％。结论：血清学检查阳性有助于小肠活检组织病理学特征改变的患者的诊断。为此目的最好的检测方法是IgA抗内胚层抗体或IgA抗组织转谷氨酰胺酶，两者都是高度敏感和特异的。

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