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首页> 外文期刊>Iranian journal of public health. >Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection
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Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection

机译：血清尿酸水平及其对区域动脉僵硬度和波反射的不同影响

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Background:Both increased arterial stiffness and hyperuricaemia are associated with elevated cardiovascular risks. Little is known about the relations of serum uric acid (UA) level to regional arterial stiffness and wave reflection. The aim of the study was to investigate the gender-specific association of serum UA and indices of arterial function in a community-based investigation in China.Methods:Cross-sectional data from 2374 adults (mean age 58.24 years) who underwent routine laboratory tests, regional pulse wave velocity (PWV) and pulse wave analysis measurements were analyzed in a gender-specific manner. None of the participants had atherosclerotic cardiovascular disease, chronic renal failure, systemic inflammatory disease, gout, or were under treatment which would affect serum UA level.Results:Men had higher serum UA level than women. Subjects with hyperuricaemia had significantly higher carotid-ankle PWV in both genders (P< 0.05), and the carotid-femoral PWV (PWVc-f) was higher in women (P< 0.001) while the augmentation index was marginally lower in men (P = 0.049). Multiple regression analysis showed that serum UA was an independent determinant only for PWVc-f in women (β = 0.104, P = 0.027) when adjusted for atherogenic confounders. No other independent relationship was found between UA level and other surrogates of arterial stiffness.Conclusions:Serum UA levels are associated with alterations in systemic arterial stiffness that differ in men and women. Women might be more susceptible to large vascular damage associated with hyperuricaemia.
机译：背景：动脉僵硬度增加和高尿酸血症均与心血管风险升高有关。关于血清尿酸（UA）水平与区域动脉僵硬度和波反射的关系知之甚少。本研究的目的是在中国的一项社区调查中研究血清UA与动脉功能指标的性别特异性关联。 ，区域性脉搏波速度（PWV）和脉搏波分析测量以特定性别的方式进行了分析。受试者均无动脉粥样硬化性心血管疾病，慢性肾功能衰竭，全身性炎症性疾病，痛风或接受治疗会影响血清UA水平。结果：男性的血清UA水平高于女性。患有高尿酸血症的受试者在两个性别中均具有较高的颈踝踝关节PWV（P <0.05），女性的颈动脉股动脉PWV（PWVc-f）较高（P <0.001），而男性的增强指数则较低（P = 0.049）。多元回归分析表明，如果调整动脉粥样硬化混杂因素，血清UA仅是女性PWVc-f的独立决定因素（β= 0.104，P = 0.027）。结论：血清UA水平与全身性动脉硬化的改变相关，男女之间无相关性。结论：血清UA水平与全身性动脉硬化的改变有关。妇女可能更容易遭受与高尿酸血症相关的大血管损伤。

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