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首页> 外文期刊>Iranian journal of public health. >Correlation of Serum Free Carnitine with Serum Ferritin and Vitamin C Levels in Type II Diabetic Men
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Correlation of Serum Free Carnitine with Serum Ferritin and Vitamin C Levels in Type II Diabetic Men

机译：II型糖尿病男性血清游离肉碱与血清铁蛋白和维生素C水平的相关性

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Background:Diabetes is a major health problem worldwide. Type II diabetic patients are reported to have higher ferritin and lower vitamin C concentrations. Considering the role of ascorbic acid in carnitine biosynthesis and the limited information on free carnitine correlations with ferritin and vitamin C levels in diabetic patients without microvascular complications, this case-control study was conducted to determine ferritin and vitamin C levels in hyperlipidemic-diabetic men comparing to healthy controls; the correlation of free carnitine with ferritin and vitamin C levels were also studied in these patients.Methods:Thirty-five hyperlipidemic-diabetic and seventy healthy men, were included in the study by the convenience sampling method. Body Mass Index, blood pressure, fasting blood glucose, lipid profile, ferritin and vitamin C levels were assessed in both case and control groups; moreover, serum free carnitine was measured in both groups. Dietary assessments were performed using 24 hour recall and food frequency questionnaires.Results:Blood pressure, fasting blood glucose, cholesterol, triglyceride, LDL, and HDL concentrations were significantly higher in the case group. Mean serum ferritin concentrations were higher in diabetics comparing to controls (93.22±0.27 vs. 44.66±4.23 μg/l); whereas, mean plasma vitamin C in these patients were lower than the healthy subjects (0.68±0.07 vs. 0.89±0.05). Positive correlations were observed between free carnitine and vitamin C levels.Conclusion:According to the results, it could be suggested that vitamin C supplementation in diabetic patients with hyperlipidemia might be useful. In addition, inclusion of serum ferritin assay in routine evaluation of diabetic patients could be beneficial.
机译：背景：糖尿病是世界范围内的主要健康问题。据报道，II型糖尿病患者铁蛋白高，维生素C浓度低。考虑到抗坏血酸在肉碱生物合成中的作用，以及在无微血管并发症的糖尿病患者中游离肉碱与铁蛋白和维生素C水平的相关信息有限，本病例对照研究旨在确定高血脂糖尿病男性的铁蛋白和维生素C水平。健康控制;方法：采用方便抽样方法，纳入35例高脂血症糖尿病患者和70例健康男性，研究其游离肉碱与铁蛋白和维生素C水平的相关性。病例组和对照组均评估了体重指数，血压，空腹血糖，脂质分布，铁蛋白和维生素C水平;此外，两组均测定了无血清肉碱。饮食评估使用24小时召回和食物频率问卷进行。结果：病例组的血压，空腹血糖，胆固醇，甘油三酸酯，LDL和HDL浓度显着升高。与对照组相比，糖尿病患者的平均血清铁蛋白浓度更高（93.22±0.27 vs. 44.66±4.23μg/ l）;而这些患者的平均血浆维生素C低于健康受试者（0.68±0.07对0.89±0.05）。结论：结果表明，糖尿病高脂血症患者补充维生素C可能是有益的。另外，在糖尿病患者的常规评估中包括血清铁蛋白测定可能是有益的。

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