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首页> 外文期刊>Iranian journal of public health. >Correlation of Serum Free Carnitine with Serum Ferritin and Vitamin C Levels in Type II Diabetic Men
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Correlation of Serum Free Carnitine with Serum Ferritin and Vitamin C Levels in Type II Diabetic Men

机译：II型糖尿病男性血清游离肉碱与血清铁蛋白和维生素C水平的相关性

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Abstract Background: Diabetes is a major health problem worldwide. Type II diabetic patients are reported to have higher ferritin and lower vitamin C concentrations. Considering the role of ascorbic acid in camitine biosynthesis and the limited information on free camitine correlations with ferritin and vitamin C levels in diabetic patients without microvascular complications, this case-control study was conducted to determine ferritin and vitamin C levels in hyperlipidemic-diabetic men comparing to healthy controls; the correlation of free camitine with ferritin and vitamin C levels were also studied in these patients. Methods: Thirty-five hyperlipidemic-diabetic and seventy healthy men, were included in the study by the convenience sampling method. Body Mass Index, blood pressure, fasting blood glucose, lipid profile, ferritin and vitamin C levels were assessed in both case and control groups; moreover, serum free carnitine was measured in both groups. Dietary assessments were performed using 24 hour recall and food frequency questionnaires. Results: Blood pressure, fasting blood glucose, cholesterol, triglyceride, LDL, and HDL concentrations were significantly higher in the case group. Mean serum fetritin concentrations were higher in diabetics comparing to controls (93.22±0.27 vs. 44.66±4.23 mug/l); whereas, mean plasma vitamin C in these patients were lower than the healthy subjects (0.68±0.07 vs. 0.89±0.05). Positive correlations were observed between free carnitine and vitamin C levels. Conclusion: According to the results, it could be suggested that vitamin C supplementation in diabetic patients with hyperlipidemia might be useful. In addition, inclusion of serum ferritin assay in routine evaluation of diabetic patients could be beneficial.
机译：摘要背景：糖尿病是世界范围内的主要健康问题。据报道，II型糖尿病患者铁蛋白较高，维生素C浓度较低。考虑到抗坏血酸在肌酐生物合成中的作用以及在无微血管并发症的糖尿病患者中游离肌酐与铁蛋白和维生素C水平的相关信息有限，本病例对照研究旨在确定高脂血症糖尿病男性中铁蛋白和维生素C水平的比较健康控制;在这些患者中还研究了游离肌酐与铁蛋白和维生素C水平的相关性。方法：采用便利抽样方法将35例高血脂糖尿病患者和70例健康男性纳入研究。病例组和对照组均评估了体重指数，血压，空腹血糖，血脂，铁蛋白和维生素C水平。此外，两组均测定了无血清肉碱。使用24小时召回和食物频率问卷进行饮食评估。结果：病例组的血压，空腹血糖，胆固醇，甘油三酸酯，LDL和HDL浓度显着升高。与对照组相比，糖尿病患者的平均血清铁蛋白浓度更高（93.22±0.27 vs. 44.66±4.23马克/升）;这些患者的平均血浆维生素C低于健康受试者（0.68±0.07 vs. 0.89±0.05）。游离肉碱与维生素C水平之间存在正相关。结论：根据研究结果，提示糖尿病高脂血症患者补充维生素C可能是有用的。另外，在糖尿病患者的常规评估中包括血清铁蛋白测定可能是有益的。

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