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首页> 外文期刊>Iranian journal of public health. >Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus
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Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus

机译：长链n-3脂肪酸改善2型糖尿病的抑郁症候群

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Background: Type 2 diabetes mellitus (T2DM) is commonly associated with depressive symptoms, which affect prognosis and quality of life. We investigated the antidepressant effects of n-3 fatty acids (n-3FAs) monotherapy (without conventional antidepressants) for T2DM patients with mild to moderate depressive symptoms.Methods: A 10-wk, placebo-controlled, double-blind, parallel-group (1:1 ratio) randomized trial of n-3FAs (2700 mg/day EPA: DHA ratio=2) versus placebo in 88 Iranian diabetic patients with mild to moderate depression based on Beck Depression Inventory II (BDI-II-PERSIAN) was conducted. This study started from July 2014 to January 2015 in Tehran University of Medical Sciences, Tehran, Iran. The primary event was defined as worsened, non-changed, or inconsiderably improved depression (5 unit decrease in BDI-II-PERSIAN depression scores after treatment) (ClinicalTrials.gov Identifier: NCT02261545).Results: Randomly, 44 T2DM patients were treated with n-3FAs supplements and 44 cases received placebo (three patients discontinued). n-3FAs could significantly protect patients against the aforesaid event and exhibit satisfactory prevention (number needed to treat with 95% confidence interval: 2.52, 1.71-4.74). No serious adverse reactions were reported.Conclusion: n-3FAs supplementation had significant antidepressant effects in T2DM patients with mild to moderate depressive symptoms, not confounded by metabolic factors and disease duration.
机译：背景：2型糖尿病（T2DM）通常与抑郁症状相关，抑郁症状影响预后和生活质量。我们研究了n-3脂肪酸（n-3FAs）单一疗法（无常规抗抑郁药）对患有轻度至中度抑郁症状的T2DM患者的抗抑郁作用。方法：10周，安慰剂对照，双盲，平行组根据贝克抑郁量表II（BDI-II-PERSIAN），对88例轻度至中度抑郁的伊朗糖尿病患者进行n-3FAs（2700 mg /天EPA：DHA比= 2）与安慰剂的随机对照试验（1：1比率）为进行。这项研究于2014年7月至2015年1月在伊朗德黑兰的德黑兰医科大学开始。原发事件定义为抑郁症恶化，未改变或改善不明显（治疗后BDI-II-PERSIAN抑郁评分降低了<5个单位）（ClinicalTrials.gov标识符：NCT02261545）。结果：随机治疗了44例T2DM患者接受n-3FAs补充剂治疗的患者有44例接受了安慰剂（3例患者停药）。 n-3FAs可以显着地保护患者免受上述事件的侵扰，并显示出令人满意的预防效果（需要治疗的人数（95％置信区间：2.52，1.71-4.74））。结论：n-3FAs对患有轻度至中度抑郁症状的T2DM患者具有显着的抗抑郁作用，不受代谢因素和疾病持续时间的干扰。

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