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首页> 外文期刊>Iranian journal of psychiatry. >The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne
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The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne

机译：异维A酸（rocutcutane）疗法对重度痤疮患者抑郁和生活质量的影响

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ObjectiveAcne is the most common skin disease and isotretinoin is the most powerful drug among the various drugs used for its treatment, but it has some adverse effects. The aim of this study was to evaluate the effect of isotretinoin on depression and quality of life of a group of patients undergoing isotretinoin therapy before and after the treatment course.MethodsIn this prospective study, 98 patients with severe acne were enrolled consecutively and underwent isotretinoin therapy receiving 0.5 mg/kg/d of isotretinoin for 16 weeks. Isotretinoin effects on quality of life and depression were evaluated using Dermatology Life Quality Index (DLQI) and Beck Depression Inventory (BDI) questionnaires, respectively.ResultsIn this study, 98 patients suffering from severe acne (38 males and 60 females) were enrolled. Treatment of acne was associated with improvement of quality of life scores in both male and female patients (p = 0.001). Considering the cutoff value of 13 for mild depressive mood in the BDI score, in total, 48 (49%) of the enrolled patients (21 males and 33 females) had a mild depressive mood before the commencement of the treatment in this study. The analysis of before and after treatment BDI scores showed that the number of patients and also the mean score of BDI were increased in both male and female patients after the treatment (p<0.05).ConclusionIsotretinoin therapy improved the quality of life of patients suffering from acne, but depression was accentuated in the patients to some extent.
机译：ObjectiveAcne是最常见的皮肤病，而异维A酸是用于治疗的各种药物中最有效的药物，但它有一些副作用。这项研究的目的是评估异维A酸对一组接受异维A酸治疗的患者在治疗前后的抑郁和生活质量的影响。方法在这项前瞻性研究中，连续入选98例重度痤疮患者并接受异维A酸治疗接受0.5 mg / kg / d的异维A酸治疗16周。分别使用皮肤病生活质量指数（DLQI）和贝克抑郁量表（BDI）问卷评估了异维A酸对生活质量和抑郁的影响。结果本研究共纳入98例重度痤疮患者（男38例，女60例）。痤疮的治疗与男性和女性患者生活质量得分的改善相关（p = 0.001）。考虑到BDI评分中轻度抑郁情绪的临界值为13，在本研究开始治疗之前，共有48位（49％）的患者（21位男性和33位女性）有轻度抑郁情绪。治疗前后BDI评分的分析表明，治疗后男女患者的BDI得分均增加，并且BDI的平均得分均有所提高（p <0.05）。结论异维A酸治疗改善了患有BDI的患者的生活质量痤疮，但患者的抑郁感在一定程度上加剧了。

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