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首页> 外文期刊>Iranian Journal of Pharmaceutical Research >Evaluation of Antimicrobial Properties of Conventional Poly(Methyl Methacrylate) Denture Base Resin Materials Containing Hydrothermally Synthesised Anatase TiO2 Nanotubes against Cariogenic Bacteria and Candida albicans
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Evaluation of Antimicrobial Properties of Conventional Poly(Methyl Methacrylate) Denture Base Resin Materials Containing Hydrothermally Synthesised Anatase TiO2 Nanotubes against Cariogenic Bacteria and Candida albicans

机译：含有水热合成的锐钛矿型TiO2纳米管的常规聚甲基丙烯酸甲酯假牙基树脂材料对致癌细菌和白色念珠菌的抗菌性能评价

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The purpose of this study was to investigate the antimicrobial properties of a conventionalpoly methyl methacrylate (PMMA) modified with hydrothermally synthesised titaniumdioxide nanotubes (TNTs). Minimum inhibitory concentration (MIC), minimum bactericidalconcentration (MBC), and minimum fungicidal concentrations (MFC) for planktonic cellsof the TiO2 nanotubes solution against Lactobacillus acidophilus, Streptococcus mutans andCandida albicans were determined. The powder of conventional acrylic resin was modifiedusing 2.5% and 5% by weight synthesised titanium dioxide (TiO2) nanotubes, and rectangularshapedspecimens (10 mm ?? 10 mm ?? 3 mm) were fabricated. The antimicrobial propertiesof ultraviolet (UV) and non-UV irradiated modified, and non-modified acrylic resins wereevaluated using the estimation of planktonic cell count and biofilm formation of the threemicroorganisms mentioned above. The data were analysed by one-way analysis of variance(ANOVA), followed by a post-hoc Tukeya??s test at a significance level of 5%. MIC, forStreptococcus. mutans, Lactobacillus. acidophilus, and Candida. albicans, MBC for S. mutansand L. acidophilus and MFC for Candida. albicans were obtained more than 2100 ??g/mL.The results of this study indicated a significant reduction in both planktonic cell count andbiofilm formation of modified UV-activated acrylic specimens compared with the controlgroup (p = 0.00). According to the results of the current study, it can be concluded that PMMA/TiO2 nanotube composite can be considered as a promising new material for antimicrobialapproaches.
机译：这项研究的目的是研究水热合成的二氧化钛纳米管（TNTs）改性的常规聚甲基丙烯酸甲酯（PMMA）的抗菌性能。确定了TiO2纳米管溶液对嗜酸乳杆菌，变形链球菌和白色念珠菌的浮游细胞的最小抑制浓度（MIC），最小杀菌浓度（MBC）和最小杀真菌浓度（MFC）。使用2.5重量％和5重量％的合成二氧化钛（TiO 2）纳米管对常规丙烯酸树脂的粉末进行改性，并制造矩形样品（10mm×10mm×3mm）。使用上述三种微生物的浮游细胞计数和生物膜形成的评估，评估了紫外线（UV）和非UV辐照的改性和非改性丙烯酸树脂的抗菌性能。数据通过单向方差分析（ANOVA）进行分析，然后进行显着性水平为5％的事后Tukeya ??检验。 MIC，用于链球菌。变形菌，乳杆菌。嗜酸菌和念珠菌。白色念珠菌，变形链球菌和嗜酸乳杆菌的MBC和念珠菌的MFC。所得到的白色念珠菌的浓度超过2100μg/ mL。这项研究的结果表明，与对照组相比，改性的UV活化的丙烯酸样品的浮游细胞数和生物膜形成均显着降低（p = 0.00）。根据目前的研究结果，可以得出结论，PMMA / TiO2纳米管复合材料可以被认为是一种有前途的新型抗微生物方法。

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