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首页> 外文期刊>Istituto Superiore di Sanita. Rendiconti >From bench to bedside and to health policies (and back): ethics in translational research
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From bench to bedside and to health policies (and back): ethics in translational research

机译：从工作台到床头到卫生政策（前后）：转化研究中的伦理

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INTRODUCTION: The medical aim of translational research is to smooth the transition of discoveries made through basic research from the laboratory bench to their diagnostic or therapeutic applications for patients. These applications may be extended to current clinical practice and to health policies. AIM: The converse is also important: health policies should provide a point of departure when identifying research priorities. Translational research poses the same ethical problems as trials with human subjects - albeit in different ways. One of the more significant problems is the risk for participants in trials: it is thus necessary to ensure that the risks to which these subjects are exposed are not out of proportion to the expected benefits. DISCUSSION: Translational research does not require new ethical principles, but existing biomedical principles need to be adjusted to the specific context. The well-being of participants should always be the primary objective; these persons should never be considered as means for the advancement of knowledge or for the improvement of applications.
机译：引言：转化研究的医学目的是使通过基础研究发现的发现从实验室工作平台过渡到其对患者的诊断或治疗应用中，是平滑的。这些应用可以扩展到当前的临床实践和健康政策。目的：相反也很重要：在确定研究重点时，卫生政策应提供切入点。转化研究提出的伦理问题与人类受试者面临的伦理问题相同，尽管方式不同。更为严重的问题之一是试验参与者的风险：因此有必要确保这些受试者面临的风险与预期收益不成比例。讨论：转化研究不需要新的伦理原则，但是现有的生物医学原则需要根据具体情况进行调整。参与者的福祉应始终是首要目标;这些人员绝对不应被视为提高知识或改善应用程序的手段。

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