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首页> 外文期刊>Iranian Journal of Immunology >Evaluation of the Serum Levels of Immunoglobulin and Complement Factors in b-thalassemia Major Patients in Southern Iran
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Evaluation of the Serum Levels of Immunoglobulin and Complement Factors in b-thalassemia Major Patients in Southern Iran

机译：伊朗南部b地中海贫血重症患者血清免疫球蛋白和补体因子的评估

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Background: Beta-thalassemia major is one of the major health problems in our country. Many studies have confirmed the fact that, these patients have an increased susceptibility to bacterial infections. Objective: In this study, we have assessed the humoral immune system in 68 thalassemic patients by measuring their serum concentration of Immunoglobulin G (IgG), IgM, IgA, C3 and C4 in order to find out a responsible immune defect. Methods: Sixty eight b-thalassemia major patients were enrolled randomly from referrals to Dastgheib clinic of thalassemia. The same number of case controls with matched age and sex were selected from healthy people without any history of recent or recurrent infections. Serum IgG, IgM, IgA, C3 and C4 levels were assessed using Single Radial Immunodiffusion (SRID). Results: Serum levels of IgG, IgM & IgA were significantly higher (P0.01) and those of C3 and C4 were significantly lower (P0.01) in thalassemic patients than the controls. Considering the result of analytic tests, it was revealed that, thalassemia patients show much more increase in serum immunoglobulin levels as they get older. Splenectomized patients had higher serum IgG and IgA levels than non-splenectomized patients but had no difference in serum IgM, C3 and C4. Serum ferritin level had no correlation with the changes of humoral immunity; however, patients with serum ferritin level 2500ng/ml had higher serum IgM level. Conclusion: These results can be due to continuous exposure to antigens, repeated infections, chronic liver disease and splenectomy but not iron overload. The only probable cause of humoral immune deficiency found in these patients is a defect in serum complement levels.
机译：背景：β地中海贫血是我国的主要健康问题之一。许多研究证实了以下事实：这些患者对细菌感染的敏感性增加。目的：在这项研究中，我们通过测量68名地中海贫血患者的免疫球蛋白G（IgG），IgM，IgA，C3和C4血清浓度来评估其体液免疫系统，以找出负责任的免疫缺陷。方法：从转诊到地中海贫血的Dastgheib诊所随机招募了68名b型地中海贫血重症患者。从健康人群中选择相同数量的年龄和性别相匹配的病例对照，没有任何近期或复发感染的病史。血清IgG，IgM，IgA，C3和C4水平采用单径流免疫扩散（SRID）进行评估。结果：地中海贫血患者的血清IgG，IgM和IgA水平明显高于对照组（P <0.01），而C3和C4的血清水平明显低于对照组（P <0.01）。考虑到分析测试的结果，结果表明，地中海贫血患者随着年龄的增长，其血清免疫球蛋白水平显着增加。脾切除的患者的血清IgG和IgA水平高于非脾切除的患者，但血清IgM，C3和C4无差异。血清铁蛋白水平与体液免疫力的变化无关。但是，血清铁蛋白水平> 2500ng / ml的患者血清IgM水平较高。结论：这些结果可能是由于持续暴露于抗原，反复感染，慢性肝病和脾切除术而不是铁超负荷引起的。在这些患者中发现的体液免疫缺陷的唯一可能原因是血清补体水平的缺陷。

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