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首页> 外文期刊>Iranian journal of medical hypotheses and ideas. >Interleukin-25 as a candidate gene in immunogene therapy of pancreatic cancer
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Interleukin-25 as a candidate gene in immunogene therapy of pancreatic cancer

机译：白细胞介素25作为胰腺癌免疫基因治疗的候选基因

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Pancreatic cancer is an aggressive type of malignancy. Generally, its promotion and progression are due to the disturbance in some cellular and molecular mechanisms, particularly deregulation of programmed cell death or apoptosis. Certainly, loss of counterbalance between generation and cell death will lead to the tumoural mass development in various tissues, such as pancreas. From earlier decades, a variety of treatments as chemotherapy, radiation and surgery have been employed in order to pancreatic cancer remedial purposes, which are associated with infirm medical outcome. Therefore, with regard to the anti-cancerous and pro-apoptotic properties of the cytokine interleukin-25 (IL-25), the authors intend to anticipate a new therapeutic strategy. IL-25 – known as IL-17E – is one of the major factors responsible for death receptor-mediated pathway. Broadly, its receptor is located on multifarious cells such as pancreatic cancerous cells. We proposed to select four groups of C57BL/6 mice, for IL-25 gene inoculation, via mesenchymal stem cells as a vector, in order to increase exposure of cancerous cells to IL-25. IL-25 could activate apoptotic mediators including tumour necrosis factor receptor associated factor (TRAF6), Fas-Associated protein with Death Domain (FADD) and caspases consequently. Probably this method will be efficient in pancreatic malignancy treatment, via inducing apoptosis in pancreatic tumoural cells.
机译：胰腺癌是一种恶性肿瘤。通常，其促进和发展是由于某些细胞和分子机制的紊乱，特别是程序性细胞死亡或凋亡的失调。当然，在生成和细胞死亡之间失去平衡的损失将导致各种组织（例如胰腺）中的肿瘤块发展。从早期的几十年开始，为了胰腺癌的修复目的已经采用了多种疗法，例如化学疗法，放射疗法和外科手术，这与医疗效果不佳相关。因此，关于细胞因子白介素25（IL-25）的抗癌和促凋亡特性，作者打算期待一种新的治疗策略。 IL-25（称为IL-17E）是导致死亡受体介导的途径的主要因素之一。广义上讲，其受体位于多种细胞如胰腺癌细胞上。我们建议选择四组C57BL / 6小鼠，通过间充质干细胞作为载体接种IL-25基因，以增加癌细胞对IL-25的暴露。因此，IL-25可以激活凋亡介体，包括肿瘤坏死因子受体相关因子（TRAF6），与Fas相关的具有死亡结构域的蛋白（FADD）和胱天蛋白酶。通过诱导胰腺肿瘤细胞凋亡，该方法可能在胰腺恶性肿瘤治疗中有效。

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