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首页> 外文期刊>Iranian journal of medical hypotheses and ideas. >Introducing the immunomodulatory effects of mesenchymal stem cells in an experimental model of Beh?et’s disease
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Introducing the immunomodulatory effects of mesenchymal stem cells in an experimental model of Beh?et’s disease

机译：在Beh？et病实验模型中引入间充质干细胞的免疫调节作用

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Beh?et’s disease (BD) is a systemic vasculitis which is characterised by oral, aphthous ulcers, genital ulcers, skin lesions and ocular manifestations. Although the aetiopathogenesis of BD is still unknown, the critical role of Th1 immune responses, neutrophil hyperactivation alongside overproduction of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-6, IL-8, tumour necrosis factor-alpha (TNFα) and particularly IL-17 have been demonstrated in the immunopathogenesis of the disease. Despite significant progress in understanding of the aetiology of the disease, its treatment remains intricate, and is still treated with immune-suppressive drugs and biological agents with probable systemic side effects. Accordingly, there is a necessity to establish the more efficient and less toxic therapeutic methods which may offer a long-time remission of BD.
机译：贝赫特氏病（BD）是一种系统性血管炎，其特征是口腔，口疮，生殖器溃疡，皮肤病变和眼部表现。尽管尚不清楚BD的发病机理，但Th1免疫反应，嗜中性粒细胞过度活化以及促炎性细胞因子（如白介素-1（IL-1），IL-6，IL-8，肿瘤坏死因子-α）过量产生的关键作用（TNFα），尤其是IL-17已在该疾病的免疫发病机理中得到证实。尽管在了解该病的病因方面取得了重大进展，但其治疗仍然十分复杂，并且仍在用免疫抑制药物和可能具有全身性副作用的生物制剂进行治疗。因此，有必要建立更有效和毒性较小的治疗方法，该方法可以长期缓解BD。

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