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首页> 外文期刊>Eastern Mediterranean Health Journal: Al-Magallat al-Sihhiyyat li-Sarq al-Mutawassit >Interleukins 12 and 13 levels among beta-thalassaemia major patients
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Interleukins 12 and 13 levels among beta-thalassaemia major patients

机译：β地中海贫血患者中白介素12和13的水平

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摘要

The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. IL-12 levels were significantly lower among cases compared with controls (91.4 pg/mL versus 154.6 pg/mL), while IL-13 levels were significantly higher (42.5 pg/mL versus 5.7 pg/mL). There was a significant negative correlation between IL-12 and IL-13 levels among beta-thalassaemia cases (r = –0.42). Patients with beta-thalassaemia alone had higher IL-12 levels than beta-thalassaemia patients who were seropositive for chronic hepatitis B or C virus infection (140 pg/mL versus 50 pg/mL); IL-13 levels were slightly lower (65 pg/mL versus 67 pg/mL). An imbalance in the IL-12/IL-13 axis may be relevant to the pathophysiology of beta-thalassaemia.
机译：尚不清楚炎症性细胞因子在β地中海贫血的病理生理中的作用。在这项研究中，通过商业ELISA测定了来自30例未脾切除的β地中海贫血患者的有丝分裂原刺激的外周血单核细胞培养上清液中白细胞介素（IL）-12和IL-13的生产水平，这些患者患有铁超负荷，年龄和性别分别为20和匹配的健康个体。与对照组相比，IL-12水平显着降低（91.4 pg / mL与154.6 pg / mL），而IL-13显着更高（42.5 pg / mL与5.7 pg / mL）。 β地中海贫血患者中IL-12和IL-13水平之间存在显着负相关（r = –0.42）。与慢性乙型或丙型肝炎病毒感染呈血清反应阳性的β-地中海贫血患者相比，仅β-地中海贫血患者具有更高的IL-12水平（140 pg / mL对50 pg / mL）; IL-13水平略低（65 pg / mL对67 pg / mL）。 IL-12 / IL-13轴失衡可能与β地中海贫血的病理生理有关。

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