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首页> 外文期刊>EBioMedicine >Effect of Pancreatic Hormones on pro-Atrial Natriuretic Peptide in Humans
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Effect of Pancreatic Hormones on pro-Atrial Natriuretic Peptide in Humans

机译：胰腺激素对人心房利钠肽的影响

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Plasma concentrations of pro-Atrial natriuretic peptide, proANP, are decreased in obesity and diabetes. Decreased proANP concentrations have also been noted after meal intake, and recently, a glucose-mediated regulation of ANP gene expression was reported. Hence, we evaluated the effects of insulin, glucagon and glucose on plasma proANP in a series of observational and experimental studies. Six healthy men underwent seven days of bed rest. Before and after the bed rest, hyperinsulinemic euglycemic clamps with serial plasma measurements of proANP were performed. Moreover, plasma proANP was quantified in 65 individuals with normal or impaired glucose regulation. Finally, the effects of infusion-induced hyperglucagonemia were examined in ten healthy men. Bed rest decreased insulin sensitivity and plasma proANP. The decrease in proANP was not associated with insulin sensitivity and the peptide concentrations remained constant during euglycemic hyperinsulinemia and hyperglycemic hyperglucagonemia. Impaired glucose regulation was not associated with decreased proANP concentrations. Bed rest per se induces a marked decrease in plasma proANP concentrations whereas insulin resistance and impaired glucose regulation was not associated with lower proANP concentrations. Neither acute hyperinsulinemia nor hyperglucagonemia seems to affect plasma proANP. Our findings thus suggest that decreased plasma proANP concentrations occur late in the development of insulin resistance.
机译：在肥胖症和糖尿病中，心房利钠肽（proANP）的血浆浓度降低。进餐后也注意到proANP浓度降低，最近有报道称葡萄糖介导的ANP基因表达调控。因此，我们在一系列观察和实验研究中评估了胰岛素，胰高血糖素和葡萄糖对血浆proANP的影响。六个健康男人卧床休息了7天。卧床前后，均进行高胰岛素性正常血糖钳夹，并进行proANP系列血浆测定。此外，在65名血糖调节正常或受损的个体中对血浆proANP进行了定量。最后，在十名健康男性中检查了输液诱导的高血糖素的影响。卧床休息可降低胰岛素敏感性和血浆proANP。在正常血糖高胰岛素血症和高血糖高血糖素血症期间，proANP的降低与胰岛素敏感性无关，并且肽浓度保持恒定。葡萄糖调节受损与proANP浓度降低无关。卧床休息本身会导致血浆proANP浓度显着降低，而胰岛素抵抗和葡萄糖调节受损与proANP浓度降低无关。急性高胰岛素血症和高血糖素血症均未影响血浆proANP。因此，我们的发现表明，降低的血浆proANP浓度发生在胰岛素抵抗发展的后期。

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