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Commentary: Hepatitis A and E: not to be forgotten

机译:评论:甲型和戊型肝炎:不要忘记

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The World Health Organization (WHO) estimates that every year hepatitis A virus (HAV) infection causes nearly 1.4 million new cases worldwide and the hepatitis E virus (HEV) is responsible for 20 million new infections and over 3 million acute cases. Although in most cases HAV and HEV infections are self-limiting, HAV is estimated to kill 100 000 people each year [1] and HEV nearly 60 000 people annually [2]. Pregnant women are at risk of more severe disease, obstetric complications and increased mortality if infected in the third trimester of pregnancy. The faecal–oral route is a well-established mode of transmission for both HAV and HEV and in the case of HEV infection person-to-person transmission is also an important factor in sporadic cases [3]. Outbreaks of HAV and HEV are therefore manifestations of the poor sanitation practices and lack of clean water supplies often found in developing countries. Humanitarian crises with large refugee populations can also be fertile ground for hepatitis outbreaks alongside cholera or other waterborne outbreaks, as was recently seen among Syrian refugees in Iraq [4]. Understanding the importance of the risk of hepatitis outbreaks in displaced populations can help in identifying outbreaks quickly and responding to them in a timely manner to reduce mortality and morbidity.
机译:世界卫生组织(WHO)估计,每年全球甲型肝炎病毒(HAV)感染导致近140万新病例,戊型肝炎病毒(HEV)导致2000万新感染和300万以上急性病例。尽管在大多数情况下,HAV和HEV感染是自限性的,但据估计,HAV每年可杀死10万人[1],每年可杀死近6万人[2]。如果孕妇在孕晚期被感染,孕妇有患上更严重疾病,产科并发症和增加死亡率的危险。粪-口途径是HAV和HEV的一种公认的传播方式,在HEV感染的情况下,人际传播也是散发病例的重要因素[3]。因此,HAV和HEV的暴发是卫生习惯不良和发展中国家经常发现的清洁水供应不足的表现。最近在伊拉克的叙利亚难民中发现[4],大量难民的人道主义危机也可能成为肝炎暴发,霍乱或其他水源性暴发的沃土。了解流离失所者中肝炎暴发风险的重要性可以帮助快速识别暴发并及时应对,以降低死亡率和发病率。

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