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首页> 外文期刊>Eastern Journal of Medicine >The impact of HMG on follicular fluid hormone levels, embryo quality and IVF outcome
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The impact of HMG on follicular fluid hormone levels, embryo quality and IVF outcome

机译：HMG对卵泡液激素水平，胚胎质量和IVF结果的影响

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The impact of HMG on follicular fluid hormone levels, embryo quality and IVF outcome Gokce Anik Ilhan 1 , Gozde Erkanli Senturk 1 , Ozgur Oktem 2 , Fatih Durmusoglu 1 1 2 The objective of this study is to evaluate the effect of HMG on the follicular fluid hormone levels, embryo quality and IVF outcomes when added at different times of stimulation to rFSH in a long protocol. Seventy infertile women were randomized into three groups; group 1(n=23) was stimulated only with rFSH; whereas, HMG was added from the beginning (group 2, n=23) or when a 10 mm follicle developed (group 3, n=24). Follicular fluid hormone levels, day 3 embryo quality, implantation and clinical pregnancy rates were assessed. The number of grade 1 embryos, and estradiol/ progesterone ratio were significantly higher in group 2 compared to group 1. The numbers of grade 2 and 3 embryos, and day 3 embryos with less than 5 cells were significantly higher in group 1. Clinical pregnancy rate was significantly higher in group 2 than group 1. In conclusion, HMG supplementation to rFSH does not increase the number of oocytes retrieved, the number of day 3 embryos and day 3 embryos at 8-cell or more stages of development, fertilization and implantation rates. HMG supplementation from the beginning of rFSH stimulation result in improvement of clinical pregnancy rates and other indices of embryo quality such as embryo grading.
机译：HMG对卵泡液激素水平，胚胎质量和IVF结果的影响Gokce Anik Ilhan 1 ，Gozde Erkanli Senturk 1 ，Ozgur Oktem 2 ， Fatih Durmusoglu 1 1 2 这项研究的目的是评估HMG对卵泡液激素水平，胚胎质量和IVF结果的影响在较长的实验方案中，在刺激的不同时间添加到rFSH中。 70名不育妇女被随机分为三组。第1组（n = 23）仅用rFSH刺激;而HMG是从头开始添加的（第2组，n = 23），或者是在形成10 mm卵泡时添加的（第3组，n = 24）。评估卵泡液激素水平，第3天胚胎质量，着床率和临床妊娠率。与第1组相比，第2组的1级胚胎数量和雌二醇/孕酮比显着更高。第1组的2级和3级胚胎以及少于5个细胞的第3天胚胎的数量显着更高。第2组的发病率显着高于第1组。总之，向rFSH补充HMG不会增加发育，受精和植入的8细胞或更多阶段的卵母细胞数，第3天胚胎的数量和第3天胚胎的数量。费率。从rFSH刺激开始就补充HMG可以改善临床妊娠率和其他胚胎质量指标，例如胚胎分级。

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