The Association of NLR and MPV with Treatment Responses, Disease Stages, and International Prognostic Index Scores in DLBCL

Sinan Demircio?lu; Ali Do?an; ?mer Ekinci; Cengiz Demir

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The Association of NLR and MPV with Treatment Responses, Disease Stages, and International Prognostic Index Scores in DLBCL

机译：NLR和MPV与DLBCL中的治疗反应，疾病分期和国际预后指标评分的关联

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The Association of NLR and MPV with Treatment Responses, Disease Stages, and International Prognostic Index Scores in DLBCL Sinan Demircio?lu sup1/sup, Ali Do?an sup1/sup, ?mer Ekinci sup2/sup, Cengiz Demir sup1/sup sup1/supVan Yüzüncü Y?l University, Department of Hematology, Van, Turkey sup2/supF?rat University, Faculty Of Medicine, Department Of Hematology, Elaz?? INTRODUCTION: Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. International Prognostic Index (IPI) is the most commonly used scoring system predicting the prognosis. In this study, we aimed to investigate the association of Neutrophil/Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) with IPI score, treatment responses, and disease stage. METHODS: A total of 113 DLBCL patients who received R-CHOP treatment were recruited for this study. Demographic data, disease stages according to the Ann Arbor staging system, IPI scores, treatment methods, treatment responses, complete blood counts, and biochemical tests of the patients were retrospectively evaluated. RESULTS: Elevated NLR had statistically significant correlation with disease stage and IPI score (p= 0.001 and p= 0.006, respectively). However, the NLR had no statistically significant correlation with the interim-treatment and post-treatment responses (p= 0.187, and p= 0.96, respectively). MPV showed no significant relationship with disease stages (p= 0.56), IPI scores (p= 0.188), interim-treatment and post-treatment responses (p= 0.122, and p= 0.239). DISCUSSION AND CONCLUSION: In conclusion, NLR was associated with IPI score and disease stage. This suggests that NLR, a cheap and easy investigation, may be used to obtain information about the prognosis.

机译：NLR和MPV与DLBCL Sinan Demircio？lu 1 ，Ali Do？an 1 、? mer Ekinci < sup> 2 ，Cengiz Demir 1 1 范·尤金库尔大学（VanYüzüncüYll），土耳其范克大学血液学系， 2 F？大鼠大学，医学院，埃拉兹血液学系？？简介：弥漫性大B细胞淋巴瘤（DLBCL）是非霍奇金淋巴瘤最常见的亚型。国际预后指数（IPI）是预测预后的最常用评分系统。在这项研究中，我们旨在研究中性粒细胞/淋巴细胞比率（NLR）和平均血小板体积（MPV）与IPI评分，治疗反应和疾病阶段的关系。方法：本研究共招募了113位接受R-CHOP治疗的DLBCL患者。回顾性评估患者的人口统计学数据，根据Ann Arbor分期系统划分的疾病分期，IPI评分，治疗方法，治疗反应，全血细胞计数和生化检查。结果：升高的NLR与疾病阶段和IPI评分具有统计学显着相关性（分别为p = 0.001和p = 0.006）。但是，NLR与治疗中期和治疗后反应之间无统计学显着相关性（分别为p = 0.187和p = 0.96）。 MPV与疾病阶段（p = 0.56），IPI评分（p = 0.188），中期治疗和治疗后应答（p = 0.122和p = 0.239）没有显着关系。讨论与结论：总之，NLR与IPI评分和疾病分期有关。这表明，NLR是一种廉价且易于研究的方法，可用于获取有关预后的信息。

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《Eastern Journal of Medicine》 |2019年第3期|共5页
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Sinan Demircio?lu; Ali Do?an; ?mer Ekinci; Cengiz Demir;
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中图分类医药、卫生;
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Diffuse Large B-Cell LymphomaNeutrophil/Lymphocyte RatioMean Platelet VolumePrognosis;

机译：弥漫性大B细胞淋巴瘤中性粒细胞/淋巴细胞比平均血小板量预后;

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The Association of NLR and MPV with Treatment Responses, Disease Stages, and International Prognostic Index Scores in DLBCL

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