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首页> 外文期刊>Eastern Mediterranean Health Journal: Al-Magallat al-Sihhiyyat li-Sarq al-Mutawassit >Drug resistance pattern and outcome of treatment in recurrent episodes of tuberculosis
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Drug resistance pattern and outcome of treatment in recurrent episodes of tuberculosis

机译：结核反复发作的耐药模式和治疗结果

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摘要

Patterns of drug resistance in recurrent cases of tuberculosis may be different than in those without a history of treatment. In this retrospective study, the drug resistance pattern and outcome of treatment with DOTS category I (CAT I) regimen was compared in 63 recurrent cases and 872 new cases of pulmonary tuberculosis from April 2003 to January 2008 at the National Research Institute of Tuberculosis and Lung Disease in Tehran, Islamic Republic of Iran. Resistance to isoniazid and ethambutol was significantly more common in recurrent cases, but there were no differences in rates of resistance to rifampin, pyrazinamide, streptomycin or the rate of multi-drug resistant strains. Resistance to streptomycin was the most common. No significant differences in treatment outcome and deaths were found between the 2 groups. Due to the low frequency of multi-drug resistance in the recurrent cases, a CAT I regimen may be suitable for empirical therapy before drug sensitivity results become available.
机译：结核病复发病例的耐药模式可能与没有治疗史的耐药模式不同。在这项回顾性研究中，比较了2003年4月至2008年1月在美国国家结核病和肺病研究所研究的63例复发病例和872例新肺结核患者的DOTS I类（CAT I）方案的耐药模式和治疗结果。伊朗伊斯兰共和国德黑兰的疾病。对异烟肼和乙胺丁醇的耐药性在复发病例中更为普遍，但对利福平，吡嗪酰胺，链霉素的耐药率或多药耐药菌株的率无差异。对链霉素的耐药性是最常见的。两组之间在治疗结局和死亡方面无显着差异。由于复发病例中多重耐药的发生频率较低，因此在获得药物敏感性结果之前，CAT I方案可能适用于经验治疗。

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