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首页> 外文期刊>Iranian Journal of Neurology >Effect of treating helicobacter pylori infection on seizure frequency in patients with refractory epilepsy.
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Effect of treating helicobacter pylori infection on seizure frequency in patients with refractory epilepsy.

机译：治疗幽门螺杆菌感染对难治性癫痫患者癫痫发作频率的影响。

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Background: The main purpose of the current study was to determine the effect of treating helicobacter pylori (HP) infection on seizure frequency in patients with refractory epilepsy.Methods: A small sample of adult patients above 18 years of age with a diagnosis of refractory epilepsy was studied at the outpatient epilepsy clinic at Shiraz University of Medical Sciences, from January 2009 through June 2011. If and when urea breath test result was positive, an upper endoscopy with multiple gastric biopsies was requested. Rapid urease test and histopathology examination were performed. For patients with confirmed HP infection, treatment with clarithromycin, amoxicillin and omeprazole was ordered for two weeks. Seizure frequency was recorded before and after HP treatment.Results: Nine patients were recruited. Using Wilcoxon signed ranks test, seizure frequency did not differ significantly after HP treatment compared to the period before treatment (P = 0.6).Conclusion: Treating HP infection in patients with refractory epilepsy did not significantly change the seizure frequency.
机译：背景：本研究的主要目的是确定治疗幽门螺杆菌（HP）感染对难治性癫痫患者癫痫发作频率的影响。方法：一小例18岁以上的成年患者，诊断为难治性癫痫于2009年1月至2011年6月在设拉子医科大学的门诊癫痫诊所进行了研究。如果尿素呼气试验结果为阳性，则需要进行内镜检查并进行多次胃活检。快速尿素酶测试和组织病理学检查。对于确诊为HP感染的患者，订购了克拉霉素，阿莫西林和奥美拉唑治疗两周。记录HP治疗前后的癫痫发作频率。结果：招募了9例患者。使用Wilcoxon符号秩和检验，HP治疗后的癫痫发作频率与治疗前相比无显着性差异（P = 0.6）。结论：难治性癫痫患者的HP感染治疗没有明显改变癫痫发作的频率。

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