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首页> 外文期刊>Eastern Journal of Medicine >Evaluation of patients with idiopathic portal hypertension: could tissue transglutaminase antibodies predict the celiac disease ?
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Evaluation of patients with idiopathic portal hypertension: could tissue transglutaminase antibodies predict the celiac disease ?

机译：对特发性门静脉高压症患者的评估：组织转谷氨酰胺酶抗体能否预测乳糜泻？

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Evaluation of patients with idiopathic portal hypertension: could tissue transglutaminase antibodies predict the celiac disease ? Fikret G?ren 1, Ahmet Cumhur Dülger2 1Van B?lge Research and Educational Hospital, Department of Gastroenterology 2Yüzüncü Y?l University, School of Medicine, Department of Gastroenterology INTRODUCTION: Idiopathic portal hypertension(IPH) traditionally has been described as a diagnosis of exclusion in patients who have presinusoidal portal hypertension. Gut- derived serologic markers in IPH are an increasing focus of attention, but there are only a few published studies on serological markers of celiac disease in patients with IPH and the results are contradictory. Furthermore, the role of tissue transglutaminase (TTG) antibodies have not yet been identified. METHODS: This study determined what proportion of IPH patients had a seropositivity of TTG antibodies and evaluated the role of TTG antibodies in IPH. Demographics and clinical data, TTG antibodies, hematologic and biochemical parameters and radiologic studies were retrospectively reviewed in all IPH patients attending our hospital. RESULTS: 10 clinically and biopsy-proven IPH patients (8 women and 2 men) were identified, all of them were diagnosed between 2009 and 2011. IgA and G antibodies to tissue transglutaminase were evaluated in all patients. 5 patients had a positive TTG IgA, 3 patients had a positive TTG IgG and 2 of them had negative autoantibodies. No patient was IgA deficient. 6 patients were eligible for duoenal biopsy and non of them had biopsy-proven celiac disease(CD). DISCUSSION AND CONCLUSION: Although the data are limited, this study suggests that seropositivity for TTG antibodies could be positive in IPH. But there was no relation between positive serologic results and CD.
机译：对特发性门静脉高压症患者的评估：组织转谷氨酰胺酶抗体能否预测乳糜泻？ Fikret G？ren 1 ，Ahmet CumhurDülger 2 1 范伯格大学教育学院，消化内科 2 YüzüncüY？l大学，医学院，胃肠病学引言：特发性门静脉高压症（IPH）传统上已被描述为患有鼻窦前门静脉高压症的诊断。 IPH中肠源性血清学标志物已成为越来越多的关注焦点，但关于IPH患者腹腔疾病血清学标志物的公开研究很少，其结果相互矛盾。此外，尚未确定组织转谷氨酰胺酶（TTG）抗体的作用。方法：本研究确定了多少比例的IPH患者具有TTG抗体的血清阳性，并评估了TTG抗体在IPH中的作用。回顾性地回顾了我院所有IPH患者的人口统计学和临床​​数据，TTG抗体，血液和生化指标以及放射学研究。结果：确定了10例经临床和活检证实的IPH患者（8例女性和2例男性），所有患者均于2009年至2011年之间被诊断出。评估了所有患者中针对组织转谷氨酰胺酶的IgA和G抗体。 TTG IgA阳性5例，TTG IgG阳性3例，自身抗体阴性2例。没有患者是IgA缺乏的。 6例符合十二指肠穿刺活检标准，无活检证实的乳糜泻。讨论与结论：尽管数据有限，但这项研究表明TTG抗体的血清阳性在IPH中可能是阳性的。但是阳性血清学结果与CD之间没有关系。

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