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首页> 外文期刊>Eastern Mediterranean Health Journal: Al-Magallat al-Sihhiyyat li-Sarq al-Mutawassit >Changes in adrenal steroidogenesis in spontaneous bacterial peritonitis and sterile ascites
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Changes in adrenal steroidogenesis in spontaneous bacterial peritonitis and sterile ascites

机译：自发性细菌性腹膜炎和无菌腹水肾上腺类固醇生成的变化

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摘要

Adrenal androgens, particularly dehydroepiandrosterone (DHEA), may have important regulatory effects on the immune system in humans. This study measured the changes in adrenal steroidogenesis in 13 non-infected cirrhosis patients with sterile ascites and 13 patients with spontaneous bacterial peritonitis and the relation with circulating interleukin-6 (IL-6) levels. Comparisons were made with 10 healthy age-matched control subjects. The severity of bacterial peritonitis in liver cirrhosis was significantly associated with enhanced serum IL-6 and cortisol levels, and a decrease in serum DHEA sulfate in relation to serum IL-6 concentrations. Careful, long-term studies on DHEA administered to cirrhosis patients are needed to assess its safety in improving a number of pathological conditions that complicate liver cirrhosis.
机译：肾上腺雄激素，特别是脱氢表雄酮（DHEA），可能对人类免疫系统具有重要的调节作用。这项研究测量了13例非感染性腹水的非感染性肝硬化患者和13例自发性细菌性腹膜炎的肾上腺类固醇生成的变化及其与循环白细胞介素6（IL-6）水平的关系。与10名年龄匹配的健康对照者进行了比较。肝硬化中细菌性腹膜炎的严重程度与血清IL-6和皮质醇水平升高以及血清DHEA硫酸盐相对于血清IL-6浓度的降低显着相关。需要对给予肝硬化患者的DHEA进行长期的仔细研究，以评估其在改善许多使肝硬化复杂化的病理状况方面的安全性。

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