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首页> 外文期刊>EBioMedicine >Low Very low-Density Lipoprotein Cholesterol but High Very low-Density Lipoprotein Receptor mRNA Expression in Peripheral White Blood Cells: An Atherogenic Phenotype for Atherosclerosis in a Community-Based Population
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Low Very low-Density Lipoprotein Cholesterol but High Very low-Density Lipoprotein Receptor mRNA Expression in Peripheral White Blood Cells: An Atherogenic Phenotype for Atherosclerosis in a Community-Based Population

机译：低非常低密度脂蛋白胆固醇但高非常低密度脂蛋白受体mRNA表达的外周血白细胞：动脉粥样硬化的基于社区的人群的致热表型。

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摘要

Very low-density lipoprotein cholesterol (VLDL-C), via binding very low-density lipoprotein receptor (VLDLR), can induce the development of atherosclerosis. Besides monocytes, VLDLR expression is detected in various peripheral white blood cells (WBCs), yet its underlying role remains unclear. We thereby aimed to test the hypothesis that VLDLR in all types of peripheral WBCs may be involved in the association between VLDL-C and atherosclerosis. VLDLR mRNA expression in peripheral WBC and plasma VLDL-C levels were measured in 747 participants from a community-based study. Plaque prevalence and total plaque area (TPA) were used to evaluate the burden of carotid atherosclerosis. VLDL-C was positively associated with atherosclerosis risk, whereas this association was modified by VLDLR mRNA level. In participants with the lowest VLDL-C but the highest VLDLR mRNA expression, the risk for plaque prevalence unexpectedly was the highest. This association was also observed for TPA. Moreover, this association remained unchanged after adjusting for WBC or monocytes. Our findings described an atherogenic phenotype characterized by low VLDL-C but high VLDLR mRNA expression in peripheral WBCs, which suggested that VLDLR in all types of peripheral WBCs may be involved in lipid deposition, and VLDL-C and VLDLR may co-determine the development of atherosclerosis.
机译：通过结合极低密度脂蛋白受体（VLDLR），极低密度脂蛋白胆固醇（VLDL-C）可以诱导动脉粥样硬化的发展。除单核细胞外，还在各种外周白细胞（WBC）中检测到VLDLR表达，但其潜在作用仍不清楚。因此，我们旨在检验以下假设：所有类型的外周血白细胞中的VLDLR可能参与VLDL-C与动脉粥样硬化之间的关联。在一项基于社区的研究中，对747名参与者进行了外周白细胞和血浆VLDL-C水平中VLDLR mRNA表达的测量。斑块患病率和总斑块面积（TPA）用于评估颈动脉粥样硬化的负担。 VLDL-C与动脉粥样硬化风险呈正相关，而这种关联因VLDLR mRNA水平而改变。在VLDL-C最低但VLDLR mRNA表达最高的受试者中，斑块患病风险出乎意料地最高。对于TPA也观察到这种关联。此外，在调整了WBC或单核细胞后，这种关联仍然保持不变。我们的发现描述了以外周血白细胞中VLDL-C低但VLDLR mRNA表达高为特征的动脉粥样硬化表型，这表明所有类型的外周血白细胞中的VLDLR可能参与脂质沉积，而VLDL-C和VLDLR可能共同决定发育的动脉粥样硬化。

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