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首页> 外文期刊>EBioMedicine >Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
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Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

机译：细胞衰老中的线粒体：线粒体是最弱的环节吗？

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Cell senescence is increasingly recognized as a major contributor to the loss of health and fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; oxidative phosphorylation efficiency is decreased and reactive oxygen species production is increased. In this review we will discuss how the turnover of mitochondria (a term referred to as mitophagy) is perturbed in senescence contributing to mitochondrial accumulation and Senescence-Associated Mitochondrial Dysfunction (SAMD). We will further explore the subsequent cellular consequences; in particular SAMD appears to be necessary for at least part of the specific Senescence-Associated Secretory Phenotype (SASP) and may be responsible for tissue-level metabolic dysfunction that is associated with aging and obesity. Understanding the complex interplay between these major senescence-associated phenotypes will help to select and improve interventions that prolong healthy life in humans. Search strategy and selection criteria: Data for this review were identified by searches of MEDLINE, PubMed, and references from relevant articles using the search terms ''mitochondria AND senescence'', ''(autophagy OR mitophagy) AND senescence'', ''mitophagy AND aging'' and related terms. Additionally, searches were performed based on investigator names. Abstracts and reports from meetings were excluded. Articles published in English between 1995 and 2017 were included. Articles were selected according to their relevance to the topic as perceived by the authors.
机译：细胞衰老日益被认为是与衰老相关的健康和适应性丧失的主要因素。衰老细胞会积聚功能异常的线粒体;氧化磷酸化效率降低，活性氧种类产生增加。在这篇综述中，我们将讨论如何在衰老中干扰线粒体的周转（术语称为线粒体吞噬），从而导致线粒体积累和衰老相关的线粒体功能障碍（SAMD）。我们将进一步探讨随后的细胞后果;特别地，SAMD对于特定的衰老相关的分泌表型（SASP）的至少一部分似乎是必需的，并且可能与与衰老和肥胖有关的组织水平的代谢功能障碍有关。了解这些主要的衰老相关表型之间的复杂相互作用将有助于选择和改善可延长人类健康寿命的干预措施。搜索策略和选择标准：通过检索MEDLINE，PubMed和相关文章的引用，使用搜索词“线粒体和衰老”，“（自噬或线粒体）和衰老”，``线粒体和衰老''及相关术语。此外，还根据调查员姓名进行搜索。会议摘要和报告均不包括在内。收录了1995年至2017年间以英文发表的文章。根据作者认为与主题相关的文章进行选择。

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