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首页> 外文期刊>EBioMedicine >The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study
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The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study

机译：克罗恩病中的NOD2吸烟相互作用可能特定于1007fs突变，并且可能在诊断时通过年龄来解释：一项荟萃分析和仅病例研究

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Background: NOD2 and smoking are risk factors for Crohn's disease. We meta-analyzed NOD2-smoking interactions in Crohn's disease (Phase 1), then explored the effect of age at diagnosis on NOD2-smoking interactions (Phase 2). Methods: Phase 1: MEDLINE and EMBASE were searched for studies (n=18) providing data on NOD2 and smoking in Crohn's disease. NOD2-smoking interactions were estimated using odds ratios (ORs) and 95% confidence intervals (CIs) calculated using random effects models. Phase 2: A case-only study compared the proportion of smokers and carriers of the 1007fs variant across ages at diagnosis (@?16, 17-40, >40years). Findings: Phase 1: Having ever smoked was less common among carriers of the 1007fs variant of NOD2 (OR 0.74, 95%CI:0.66-0.83). There was no interaction between smoking and the G908R (OR 0.96, 95%CI:0.82-1.13) or the R702W variant (OR 0.89, 95%CI:0.76-1.05). Phase 2: The proportion of patients (n=627) carrying the 1007fs variant decreased with age at diagnosis (@?16years: 15%; 17-40: 12%; >40: 3%; p=0.003). Smoking was more common in older patients (@?16years: 4%; 17-40: 48%; >40: 71%; p<0.001). Interpretation: The negative NOD2-smoking interaction in Crohn's disease is specific to the 1007fs variant. However, opposing rates of this variant and smoking across age at diagnosis may explain this negative interaction.
机译：背景：NOD2和吸烟是克罗恩氏病的危险因素。我们对克罗恩病（阶段1）的NOD2吸烟相互作用进行了荟萃分析，然后探讨了诊断时的年龄对NOD2吸烟相互作用的影响（阶段2）。方法：阶段1：在MEDLINE和EMBASE中进行研究（n = 18），以提供有关克罗恩病中NOD2和吸烟的数据。使用随机效应模型计算的比值比（OR）和95％置信区间（CI）估算NOD2吸烟相互作用。阶段2：仅病例研究比较了1007fs变体的吸烟者和携带者在诊断时的年龄比例（@？16、17-40，> 40岁）。发现：阶段1：在NOD2的1007fs变体的携带者中抽烟较少（OR 0.74，95％CI：0.66-0.83）。吸烟与G908R（OR 0.96，95％CI：0.82-1.13）或R702W变异体（OR 0.89，95％CI：0.76-1.05）之间没有相互作用。阶段2：携带1007fs变体的患者（n = 627）的比例随着诊断时的年龄而降低（@？16岁：15％; 17-40：12％;> 40：3％; p = 0.003）。吸烟在老年患者中更为常见（@ 16岁：4％; 17-40：48％;> 40：71％; p <0.001）。解释：克罗恩病中NOD2吸烟阴性反应是1007fs变异体特有的。然而，这种变异的比率和诊断时跨年龄的吸烟率可能解释了这种负面的相互作用。

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